Performances of PEG-modified hemoglobin-vesicles as artificial oxygen carriers in microcirculation

Issue title: Selected Proceedings of the 6th Asian Congress for Mirocirculation (ACM'05) (Tokyo, February 25 and 26, 2005)

Article type: Research Article

Authors: Sakai, Hiromi | Tsuchida, Eishun

Affiliations: Advanced Research Institute for Science and Engineering, Waseda University, Tokyo 169-8555, Japan

Note: [] Corresponding author. E-mail: [email protected].

Abstract: Hemoglobin-Vesicles (HbV; diameter, 250 nm) are artificial O2 carriers encapsulating purified and concentrated human Hb solution in phospholipid vesicles (liposomes), and their safety and efficacy, as a transfusion alternative, have been studied. In this paper, we summarized the characteristics of HbV that have been clarified by the microcirculatory observations.

Keywords: Blood substitutes, liposome, microcirculation, EDRF, oxygenation

Journal: Clinical Hemorheology and Microcirculation, vol. 34, no. 1-2, pp. 335-340, 2006