Serum C-reactive protein and soluble angiopoietin receptor Tie-2 in patients with acute myocardial infarction and its detection by optical proteinchip

Issue title: Selected Proceedings of the 6th Asian Congress for Mirocirculation (ACM'05) (Tokyo, February 25 and 26, 2005)

Article type: Research Article

Authors: Fu, Panfeng | Wang, Chunling | Xiu, Ruijuan

Affiliations: Institute of Microcirculation, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100005, China

Note: [] Corresponding author. E-mail: [email protected].

Abstract: Serum C-reactive protein (CRP) and soluble angiopoietin receptor Tie-2 (sTie) were detected in patients with acute myocardial infarction (AMI). The results indicated that mean serum CRP and Tie-2 levels were significantly higher in the patients with AMI than the control group. Increasing CRP was related to an increased infarction area and adverse prognosis. Levels of sTie-2 increased in the AMI patients and the maximum level of sTie-2 appeared at day 2 after onset of AMI. The feasibility of using to detect serum CRP and Tie-2 was also presented in this study. Measurement for CRP by optical proteinchip with imaging ellipsometry (OPC-IE) and immunobidimetric analyzer showed no obvious difference (p<0.01). Also, the measurement for Tie-2 by ELISA and OPC-IE showed no obvious difference (p<0.01).

Keywords: C-reactive protein (CRP), angiopoietin receptor Tie-2, optical proteinchip, acute myocardial infarction

Journal: Clinical Hemorheology and Microcirculation, vol. 34, no. 1-2, pp. 169-175, 2006