Evaluation of sickle cell aggregation by ultrasound backscattering

Article type: Research Article

Authors: Boynard, M.^a | Razavian, M.^a | Beuzardz, Y.^b

Affiliations: [a] Laboratoires de Biophysique, U.E.R. Biomédicale, 45 rue des Saints-Pères, 75270-Paris Cedex 05 et U.E.R. Médicale, 74 rue Marcel Cachin, 93000-Bobigny, France | [b] INSERM U91, Hopital Henri Mondor, 51 avenue du Maréchal de Lattre de Tassigny, 94010-Créteil, France

Note: [] Accepted by: Editor M.R. Boisseau

Abstract: The aggregation state of sickle cells was studied as a function of oxygen partial pressure, with ultrasound backscattering. The ultrasonic backscattering coefficient χ, which depends on the size of the aggregates, is highly correlated with erythrocyte sedimentation rate. Sickle cells (SS) in their plasma present a χ variation versus pO2 similar to the variation of the sickling curve. These results suggest that sickling prevent aggregation of sickle cells.

Keywords: Aggregation, Ultrasound, Red Blood Cell, Sickle cell anemia

DOI: 10.3233/CH-1988-8515

Journal: Clinical Hemorheology and Microcirculation, vol. 8, no. 5, pp. 687-694, 1988