Affiliations: N. Bokhua Center of Angiology and Vascular Surgery, 1 Chachava St., 0159 Tbilisi, Georgia | Microcirculation Research Center, I. Beritashvili Institute of Physiology, Tbilisi, Georgia
Note: [] Corresponding author: Prof. George Mchedlishvili, I. Beritashvili Institute of Physiology, 14 Gotua St., 0160 Tbilisi, Georgia. Tel.: +995 32 371016; Fax (Telecom Georgia): +995 32 00 11 53; E‐mail: [email protected].
Abstract: We investigated the RBC aggregability in the patients with the foot diabetic gangrenes: in the venous blood samples taken from the damaged foot before its amputation, as well as from the cubital vein (the systemic circulation). The RBC aggregability was investigated with the “Georgian technique” that is sensitive and provided us with direct and quantitative data. We found that the RBC aggregability was higher by about 20%, in the blood flowing from the gangrenous tissue than in the systemic circulation. Therefore, the sources of the systemic hemorheological disorders were the primarily damaged tissues. Taking into account that the blood is uninterruptedly flowing and mixing together in the whole circulatory bed we conclude that in the systemic circulation a certain compensatory mechanism provide for a partial normalization of the blood rheological properties, since the RBC aggregability never reaches the level in the blood of the healthy people.
