Affiliations: Lipoprotein and Hemorheology Research Facility, Department of Medicine and Pathology, Rush‐Presbyterian‐St. Luke's Medical Center, Chicago, IL, USA | Department of Clinical Nutrition, Rush‐Presbyterian‐St. Luke's Medical Center, Chicago, IL, USA | Preventive Cardiology Center, Northwestern University Medical School, Chicago, IL, USA
Note:  Present address: George A. Vlastos, Ph.D., GSF‐Research Center for Environment and Health, Institute for Clinical Molecular Biology and Tumor Genetics, Marchioninistrasse 25, D‐81377, Miünchen, Germany. E‐mail: [email protected]
Note:  Corresponding author: Robert S. Rosenson, M.D., Northwestern University Medical School, Preventive Cardiology Center, 201 E. Huron, Suite 11‐120, Chicago, IL 60611, USA. Tel.: +1 312 695 0013; Fax: +1 312 695 0047; E‐mail: r‐[email protected]
Abstract: This study investigated the impact of oral fluid intake on blood rheology of 17 healthy adults following a 12–14 hour overnight fast from food and drink. An oral fluid load of 500 ml was consumed every 30 minutes for 2 hours. Blood viscosity values at shear rates of 1, 10 and 100 s−1 were reduced (p<0.05 to p<0.01) at 30 and 120 minutes following hydration; however, these differences were not significant after hematocrit correction. With fluid intake, both uncorrected and corrected viscous component of blood viscoelasticity at oscillatory shear rate of 1 s−1 and at a constant frequency of 2 Hz were reduced (p<0.05 to p<0.001) at all time points as compared to fasting values. The corrected elastic component of blood viscoelasticity increased 90 minutes after hydration (p<0.05). An overnight fast is accompanied by rheological abnormalities that are altered by fluid intake.