Plenary Lecture

Issue title: The Fourth European Conference on Clinical Hemorheology. Part I. Siena, Italy, 20–22 June 1985

Subtitle: Haemorheological influences on platelet thrombogenesis

Guest editors: Alfred L. Copley, Tullio Di Perri and Sandro Forconi

Article type: Research Article

Authors: Born, G.V.R.

Affiliations: Department of Pharmacology, King’s College, London, U.K.

Abstract: This lecture is concerned mainly with questions about how haemodynamic conditions in atherosclerotic arteries affect arriving platelets that aggregate there and about the chemical agents responsible for making the platelets reactive. The effects of haemodynamic conditions and the agents are known mainly from in vitro experiments in which aggregation can be quantitatively correlated with blood flow and bioch6mical effects by simple and reproducible methods; the relevance to the more complicated situations in haemostasis and thrombosis is uncertain. It is difficult to devise quantitative in vivo methods, mainly because of the rapidity with which platelets adhere and aggregate in diseased or damaged blood vessels. Hypotheses for explaining in vivo platelet aggregation in biochemical terms must take the haemodynamic situation into account.

Keywords: platelets, haemorheology, cerebral thromboembolism

DOI: 10.3233/CH-1985-5607

Journal: Clinical Hemorheology and Microcirculation, vol. 5, no. 6, pp. 891-897, 1985