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Article type: Research Article
Authors: Stuart, J.; * | Stone, P.C.W. | Bareford, D. | Bilto, Y.Y.
Affiliations: Department of Haematology, The Medical School, University of Birmingham, Birmingham B15 2TJ, UK
Correspondence: [*] Correspondence to Professor J. Stuart.
Note: [] Accepted by: Editor J.A. Dormandy
Abstract: Initial-flow-rate filtration of erythrocytes was studied using a Hemorheometre fitted with straight-channel polycarbonate and tortuous-channel silver membranes of both 3 and 5 μm pore diameter. Erythrocyte filtration through straight-channel 3 μm pores was sensitive to in vitro manipulation of erythrocyte mean cell volume (MCV) and correlated with patients’ MCV in four clinical groups; 3 μm pore filtration was also sensitive to laboratory temperature even within the range 20–25°C. Rheological studies using 3 μm pores therefore require strict observance of buffer pH and osmolality, which affect MCV, and also filtration temperature. Filtration through 5 μm pores was less dependent on MCV in vitro, and in the clinical groups, but was sensitive to in vitro increase in mean cell haemoglobin concentration (MCHC). Use of both 3 and 5 μm diameter pores in filtration studies will increase test sensitivity to different determinants of erythrocyte deformability.
Keywords: Rheology, Erythrocyte deformability, Erythrocyte indices
DOI: 10.3233/CH-1985-5508
Journal: Clinical Hemorheology and Microcirculation, vol. 5, no. 5, pp. 449-461, 1985
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