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Article type: Research Article
Authors: Garnier, M.a | Koutsouris, D.a; b; * | Hanss, M.a; b; †
Affiliations: [a] Laboratoires de Biochimie et de Biophysique, U.E.R. Santé – Médecine – Biologie, 74, rue Marcel Cachin, 93012 Bobigny Cedex, France | [b] Laboratoire de Biophysique, U.E.R. Biomédicale des Sts-Pères, 45, rue des Sts-Pères, 75270 Paris Cedex 06, France
Correspondence: [*] Address correspondence to: D. KOUTSOURIS, Faculté de Médecine, 74, rue Marcel Cachin, 93000 Bobigny (France).
Note: [1] Presented at 1983, 3rd European Conference on Clinical Hemorheology, Baden-Baden.
Note: [†] Deceased.
Note: [] Accepted by: Editor G.A. Marcel
Abstract: Using two different technical approaches (modified Reid and Dormandy and initial filtration flow rate methods), the RBC deformability has been determined under various conditions, in order to estimate the role of the membrane. On normal human RBCs, the rigidity index (IR) is the same for the whole cell as for the membranes. The thermal variations of IR (between 5 and 40°C) are the same for the whole cells as for the ghosts. Moreover they show the same low temperature transition as the one presented by natural and artificial lipid bilayers. Using RBC from various species of mammals, the filtration indices of the intact cells and of the ghosts are only correlated with the membrane cholesterol/phospholipids ratio. Therefore, we think that, in the above mentioned conditions, the RBC deformability is mainly controlled by its membrane composition and organization.
Keywords: erythrocyte, membrane, deformability, lipids
DOI: 10.3233/CH-1985-5503
Journal: Clinical Hemorheology and Microcirculation, vol. 5, no. 5, pp. 401-409, 1985
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