The mechanism of cell rejection in membrane plasmapheresis

Issue title: Proceedings of the Third European Conference on Clinical Hemorheology. Part III. Baden-Baden, F.R. Germany, 24–27 August 1983. Symposium IV. Rheological Aspects of Plasma Separation and Plasmapheresis

Guest editors: Alfred L. Copley and Holger Schmid-Schönbein

Article type: Research Article

Authors: Vassilieff, Christian S.^{; *} | Leonard, Edward F. | Stepner, Tova A.

Affiliations: Artificial Organs Research Laboratory, Columbia University, New York, N.Y. 10027, U.S.A.

Note: [*] On leave from the University of Sofia, Bulgaria.

Abstract: To keep plasmapheresis membranes unclogged, shear flow of blood over them is necessary, but the role of shear has not been established. A simple convection mechanism, applicable only to finite-sized particles, is described and shown to correlate available plasmapheresis data better than the “lift” and “concentration polarization” models previously proposed.

Keywords: plasmapheresis, cross-flow filtration, critical flux

DOI: 10.3233/CH-1985-5103

Journal: Clinical Hemorheology and Microcirculation, vol. 5, no. 1, pp. 7-14, 1985