Comparison between two methods, viscometry and filtration, for red blood cell deformability evaluation. Effect of pentoxifylline

Article type: Research Article

Authors: Bucherer, C. | Lacombe, C. | Lelievre, J.C.

Affiliations: Unité de Biorhéologie, équipe du Laboratoire Associé au CNRS LA 343, Département de Biophysique, CHU Pitié-Salpêtrière, 91 bd de l’Hôpital 75634 Paris Cedex 13, France

Note: [] Accepted by: Editor G.A. Marcel

Abstract: The modification of erythrocyte deformability, observed when one adds pentoxifylline in vitro, are studied using two methods. The filtration method (Hanss hemorheometer) allows, from filtration time measurements, to determine a filtration parameter. The viscometric method (Couette viscometer) allows, from shear-thinning measurements, to evaluate a viscometric parameter. These two parameters, which can characterize, to a certain extent, red blood cell deformability, are compared statistically. Furthermore, using those methods, the effect of pentoxifylline is evaluated on normal cells.

Keywords: red cell deformability, viscometry, filtration, pentoxifylline

DOI: 10.3233/CH-1984-4402

Journal: Clinical Hemorheology and Microcirculation, vol. 4, no. 4, pp. 387-393, 1984