Clinical approach to disturbances in microcirculation of the heart

Issue title: Proceedings of Fifth International Congress of Biorheology. Baden-Baden, F.R. Germany, 20–24 August 1983. Symposium on Hemorheological Disorders in Cardiovascular Diseases

Guest editors: Alfred L. Copley and Siegfried Witte

Article type: Research Article

Authors: Strauer, Bodo E. | Böhme, Heinz | Samtleben, Werner | Schulig, Sabine | Volger, Ernst

Affiliations: Department of Medicine, University of München, Klinikum Großhadern, P.O. Box 701260, 0-8000 München 70, Fed.Rep. Germany

Abstract: Disorders in coronary microcirculation are mainly due to vascular diseases and to rheological abnormalities. In vascular diseases (hypertensive microangiopathy, systemic immune complex vasculitis etc.) resting coronary blood flow may be normal, whereas coronary reserve is markedly restricted. In rheological diseases (paraproteinemia, polyglobulia, hyperlipoproteinemia etc.) resting coronary blood flow is mostly decreased and the coronary reserve is also limited. By normalization of the vascular component of coronary resistance (immune complex vasculitis) considerable improvement in coronary hemodynamics may be achieved (steroids, immune suppressive agents etc.) By normalization of the rheological component of coronary resistance (paraproteinemia, polyglobulia etc.) improvement in coronary hemodynamics can be achieved comparable with vascular diseases (blood letting, plasmapheresis etc.)

Keywords: Coronary microcirculation, vascular diseases, rheological disorders

DOI: 10.3233/CH-1984-4107

Journal: Clinical Hemorheology and Microcirculation, vol. 4, no. 1, pp. 45-66, 1984