Affiliations: Department of Biomaterials, University of Ulm, Albert‐Einstein‐Allee 47, 89081 Ulm, Germany | Dresdner Institut für Herz‐ und Kreislaufforschung, Forststraße 5, Dresden, Germany
Note: [] Corresponding author: Prof. Dr. F. Jung, Dresdner Institut für Herz‐ und Kreislaufforschung, Forststraße 5, 01099 Dresden, Germany. Fax: +49 351 806 4199; E‐mail: [email protected].
Abstract: Does a NO‐donor (Corvaton®, Aventis, France) attenuate the adherence and the aggregation of platelets in a closed‐loop perfusion modell with or without the implantation of coronary stents? SIN‐1, the active metabolite of molsidomine, exerted a strong influence on the interaction of platelets with the surfaces of stents. When SIN‐1 was added the adherence of platelets to the surfaces of stents was markedly reduced. The sites were most of the platelets adhered to, also changed. More platelets adhered to the stent backbone and less to the free modular stent parts. The localisation of adherent platelets could easily be shown by light microscopy. The aggregation of platelets, accompanied by a spheroidic shape change, could be demonstrated by scanning electron microscopy on the addition of an NO‐donor, not only a reduction of platelet adherence was realised but also the reduction of platelet aggregation.
