Searching for just a few words should be enough to get started. If you need to make more complex queries, use the tips below to guide you.
Article type: Research Article
Authors: Wen, Zongyao; | Yao, Weijuan | Xie, Lide | Yan, Zong‐yi | Chen, Kai | Ka, Weibo | Sun, Dagong
Affiliations: Department of Medical Physics, Beijing Medical University, Beijing 100083, P.R. China | Department of Mechanics and Engineering Science, Peking University, Beijing 100871, P.R. China
Note: [] Corresponding author: Prof. Zongyao Wen, Hemorheology Center, Department of Medical Physics, Beijing Medical University, Beijing 100083, P.R. China. Tel.: +86 10 62092419; Fax: +86 10 62015582; E‐mail: [email protected].
Abstract: Surface charge was removed from RBC (erythrocyte) membrane to different degrees with biochemical methods, i.e., treatment of RBCs with neuraminidase, either using different doses for the same incubation time (1 hour) or using the same dose (75 milli‐unit) for different incubation time. Several rheological properties of the RBCs with surface charge removal were observed, including the deformation index DI (using traditional ektacytometry) orientation index (DI)or and small deformation index (DI)d (using new ektacytometry), the viscosity at low and high shear rates (using a cone‐plate rotating viscosimeter). In addition, photographs of RBCs aggregation under a microscope and the histograms of RBC aggregate size after treatment with neuraminidase were obtained. It is found from these experiments that the decrease of the surface charge of RBCs leads to the decrease in the deformation and orientation indices as well as the increase in blood viscosity.
Keywords: Erythrocytes, surface charge, neuraminidase, ektacytometry, deformation index
Journal: Clinical Hemorheology and Microcirculation, vol. 23, no. 1, pp. 51-57, 2000
IOS Press, Inc.
6751 Tepper Drive
Clifton, VA 20124
USA
Tel: +1 703 830 6300
Fax: +1 703 830 2300
[email protected]
For editorial issues, like the status of your submitted paper or proposals, write to [email protected]
IOS Press
Nieuwe Hemweg 6B
1013 BG Amsterdam
The Netherlands
Tel: +31 20 688 3355
Fax: +31 20 687 0091
[email protected]
For editorial issues, permissions, book requests, submissions and proceedings, contact the Amsterdam office [email protected]
Inspirees International (China Office)
Ciyunsi Beili 207(CapitaLand), Bld 1, 7-901
100025, Beijing
China
Free service line: 400 661 8717
Fax: +86 10 8446 7947
[email protected]
For editorial issues, like the status of your submitted paper or proposals, write to [email protected]
如果您在出版方面需要帮助或有任何建, 件至: [email protected]