Diagnostic value of CEUS combined with C-TIRADS for indeterminate FNA cytological thyroid nodules

Article type: Research Article

Authors: Zhang, Wei-Bing^{a; #} | Deng, Wen-Fang^{b; #} | He, Bei-Li^a | Wei, Ying-Ying^a | Liu, Yu^a | Chen, Zhe^a | Xu, Ren-Yan^{c; *}

Affiliations: [a] Department of Medical Ultrasound, Jiangsu Corps Hospital, Chinese People’s Armed Police Forces, Yangzhou, China | [b] Department of General Medical, Northern Jiangsu People’s Hospital of Jiangsu Province, Yangzhou, China | [c] Health Management Center, Affiliated Hospital of Yangzhou University, Yanghou University, Yangzhou, China

Correspondence: [*] Corresponding author: Ren-Yan Xu, Health Management Center, Affiliated Hospital of Yangzhou University, Yanghou University, 368 Hanjiang Road, Yangzhou, 225012, China. E-mail: [email protected].

Note: [#] These authors contributed equally to this work.

Abstract: OBJECTIVES:To investigate the diagnostic value of CEUS combined with C-TIRADS for indeterminate FNA cytological thyroid nodules. METHODS:The clinical data, ultrasonic images, C-TIRADS categories and CEUS images of 192 patients with indeterminate FNA cytological thyroid nodules confirmed by the surgical pathology were analyzed retrospectively. The diagnostic efficacy of CEUS, C-TIRADS and CEUS-TIRADS were calculated. RESULTS:The AUCs of CEUS, C-TIRADS and CEUS-TIRADS were 0.905 (95% CI: 0.862∼0.949), 0.881 (95% CI: 0.825∼0.938) and 0.954 (95% CI: 0.922∼0.986), respectively. The sensitivity, specificity, PPV, NPV, accuracy, LR– and LR+ were 84.7% (116/137), 85.5% (47/55), 93.5% (116/124), 69.1% (47/68), 84.9% (163/192), 0.179, 5.82 and 84.7% (116/137), 83.6% (46/55), 92.8% (116/125), 68.7% (46/67), 84.4% (162/192), 0.183, 5.17, 92.7% (127/137), 89.1% (49/55), 95.5% (127/133), 83.1% (49/59), 91.7% (176/192), 0.082, and 8.50, respectively. Compared with CEUS and C-TIRADS, CEUS-TIRADS had improved the AUC, sensitivity and accuracy (all P < 0.05). CONCLUSIONS:CEUS and C-TIRADS had high diagnostic values in indeterminate FNA cytological thyroid nodules. CEUS-TIRADS improved AUC, diagnostic sensitivity and accuracy, and helped to distinguish indeterminate FNA cytological nodules.

Keywords: Thyroid nodule, contrast enhanced ultrasound, Chinese thyroid imaging reporting and system

DOI: 10.3233/CH-242363

Journal: Clinical Hemorheology and Microcirculation, vol. Pre-press, no. Pre-press, pp. 1-9, 2024