Effect of alprostadil plus cilostazol on the treatment outcomes and inflammatory factors in patients with lower extremity arteriosclerosis obliterans receiving evidence-based care

Article type: Research Article

Authors: Liang, Hai^{a; #} | Liu, Panwang^{b; #} | Yang, Miao^c | Di, Panpan^a | Wu, Wei^a | Li, Huafeng^a | Liu, Yuchen^{d; *}

Affiliations: [a] Department of Pharmacy, The People’s Hospital of Bozhou, Bozhou, China | [b] Department of Pharmacy, The Second People’s Hospital of Fuyang, Fuyang, China | [c] Department of Neurology, The People’s Hospital of Bozhou, Bozhou, China | [d] Department of General Surgery, Beijing Puren Hospital, Beijing, China

Correspondence: [*] Corresponding author: Yuchen Liu, Department of General Surgery, Beijing Puren Hospital, No. 100 Chongwenwai Street, Dongcheng District, Beijing 100062, China. E-mail: [email protected].

Note: [#] Hai Liang, Panwang Liu contributed the same, as the co-first authors.

Abstract: This study aims to elucidate the effect of alprostadil (ALP) plus cilostazol (CIL) on the treatment outcomes and inflammatory factors in patients with lower extremity arteriosclerosis obliterans (LEASO) receiving evidence-based care. Firstly, 130 patients with LEASO were selected from February 2020 to February 2023 and then randomly divided into two groups with 65 patients each. Excluding the dropouts, 59 patients in the control group (6 cases of dropout) received ALP and 62 patients in the research group (3 cases of dropout) received ALP plus CIL. Both groups were cared for in accordance with the evidence-based care model. Treatment outcomes, arteriosclerosis indexes (blood flow of dorsalis pedis artery [DPA], ankle–brachial index [ABI] and toe–brachial index [TBI]), hemorheological parameters (erythrocyte aggregation index [EAI], erythrocyte deformation index [EDI], high blood viscosity [HBV] and haematocrit [HCT]), inflammatory factors (interleukin [IL]-6, IL-8 and tumour necrosis factor [TNF]-α) and complications (nausea, diarrhoea, headache and transaminase elevation) were compared between the control and research groups. Results show that the overall response rate was markedly higher in the research group (90.32%) than in the control group (74.58%). Additionally, the blood flow of DPA, ABI and TBI in the research group significantly increased after the treatment and were higher than those in the control group. Meanwhile, the EAI, EDI, HBV, HCT, IL-6, IL-8 and TNF-α were significantly lower. The two groups did not differ markedly in the complication rate. The above findings suggest that ALP plus CIL is effective for patients with LEASO receiving evidence-based care. It can significantly improve arteriosclerosis indexes and hemorheological parameters while inhibiting serum inflammatory responses, with some certain safety.

Keywords: Alprostadil, cilostazol, evidence-based care, lower extremity arteriosclerosis obliterans, treatment outcomes, inflammatory factors

DOI: 10.3233/CH-232068

Journal: Clinical Hemorheology and Microcirculation, vol. 87, no. 4, pp. 405-413, 2024