Affiliations: [a] Department of Ultrasound, The First Affiliated Hospital of Hainan Medical University, Haikou, China
| [b] Department of Ultrasound, The Second Affiliated Hospital of Nanchang University, Nanchang, China
Correspondence:
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Corresponding author: Size Wu, Department of Ultrasound, The First Affiliated Hospital of Hainan Medical University, No.31, Longhua Road, Haikou 570102, China. Tel.: +86 0898 66774347; E-mail: [email protected]. ORCID: 0000-0002-1086-764X.
Abstract: BACKGROUND:The contrast-enhanced ultrasound (CEUS) liver imaging reporting and data system (LI-RADS) is a relative new algorithm for hepatocellular carcinoma (HCC) assessment. OBJECTIVE:To validate the diagnostic efficiency of the intravascular perfusion based CEUS LI-RADS for HCC. METHODS:Archives of 873 patients with focal liver lesions (FLLs) undergoing CEUS were reviewed, and target images were read by two sonologists independently according to the CEUS LI-RADS. The diagnostic performance was calculated and compared. RESULTS:Assessment with reference to CEUS LI-RADS, 87 of 218 FLLs (39.9%) were categorized as LR-5, 131 of 218 FLLs (60.1%) were categorized as non-LR-5, 19 of 99 HCCs were categorized as non-LR-5, and 7 of 119 non-HCCs were categorized as LR-5. The sensitivity, specificity, AUROC, positive and negative predictive values of CEUS LI-RADS for diagnosing HCC were 80.81%(95%CI: 71.7%–88.0%), 94.1%(95%CI: 88.3%–97.6%), 0.87 (95%CI: 0.82–0.92), 91.9%(95%CI: 84.1%–96.7%), and 85.5%(95%CI: 78.3%–91.0%), respectively. CONCLUSIONS:The diagnostic efficiency of the intravascular perfusion based CEUS LI-RADS for the evaluation of HCCs is very good.
Keywords: Liver, focal liver lesion (FLL), hepatocellular carcinoma (HCC), contrast-enhanced ultrasound (CEUS), liver imaging reporting and data system (LI-RADS)
