Hemodilution in peripheral occlusive disease: A hemorheological approach

Issue title: Microcirculation, Interstitium, Lymph, Pathophysiology and Disease. Proceedings of the International Symposium, Villa La Principessa, Lucca, Italy, June 19–20, 1981

Guest editors: Siegfried Witte

Article type: Research Article

Authors: Meßmer, K.^a | Sunder-Plassmann, L.^b | v. Hesler, H.^a | Endrich, B.^a

Affiliations: [a] Department of Experimental Surgery, Surgical Center, University Heidelberg, 6900 Heidelberg, F.R.G. | [b] Department of Surgery, Klinikum Grosshadern, University of Munich, 8000 München, F.R.G.

Abstract: Hemorheological disorders include both impairment of the flow properties and the flow conditions of blood. Hyperviscosity of blood and the low flow are the most important prominent factors to cause hemorheological abnormalities. Since impaired fluidity of blood and uneven distribution of blood flow was found in peripheral vascular occlusive disease, improvement of blood fluidity by hemodilution has been suggested as a form of conservative treatment. To further substantiate the few clinical studies available, the effects of hemodilution were analysed in an experimental model of peripheral arterial occlusive disease. The study comprised analysis of collateral blood flow, segmental vascular resistance, distribution of resting and hyperemia flow as well as local oxygen supply to the skeletal muscle. Hemodilution by Dextran 60 was found a most effective method to decrease collateral vessel blood flow and to improve tissue oxygen supply by cancelling of the pathologic inhomogeneity of microflow.

Keywords: Hemodilution, peripheral vascular occlusion, hyperviscosity, Dextran 60, collateral vessel

DOI: 10.3233/CH-1982-25-627

Journal: Clinical Hemorheology and Microcirculation, vol. 2, no. 5-6, pp. 721-731, 1982