Searching for just a few words should be enough to get started. If you need to make more complex queries, use the tips below to guide you.
Issue title: Microcirculation, Interstitium, Lymph, Pathophysiology and Disease. Proceedings of the International Symposium, Villa La Principessa, Lucca, Italy, June 19–20, 1981
Guest editors: Siegfried Witte
Article type: Research Article
Authors: Lee-Kelland, S. | Floyer, M.A.
Affiliations: The Medical Unit, The London Hospital Medical College, London E1 2AD
Abstract: There are two pressures in the tissues which affect the flow of fluid across the capillary wall: the interstitial hydrostatic and oncotic pressures. The methods used to measure these pressures have been the subject of controversy and this has led to some doubt about the correct values. The manometer described below was designed to minimise the problem of scar tissue formation, slow equilibration and inflammation encountered in other techniques. Two types of membrane are used. The first is a large pore membrane which allows the measurement of the sum of the hydrostatic pressure and the pressure due to the interstitial matrix. The second is a small pore membrane which permits the determination of the sum of the hydrostatic and oncotic pressures in the interstitium. The aim of the manometer design is to achieve extremely rapid measurement of pressures. Equilibration can usually be obtained in 1–2 minutes, although with some membranes as little as 30 seconds is required. When the subcutaneous fascia of the ventral abdomen of the rat is rapidly exposed and the membranes place on it, the following pressures are found. The large pore membrane gives a mean pressure of −1.85 cmH2O (S.D. 0.7, n = 20) in the superficial fascia and a mean pressure of −1.85 cmH2O (S.D. 0.8, n = 7) on the fibrous tissue overlying the abdominal muscles. The small pore membrane gives a mean pressure of −12.53 cmH2O (S.D. 2.57, n = 13) on the superficial fascia and the same pressure on the fibrous tissue overlying the muscles. Subtraction of the pressure found with the large pore membranes from that found with the small pore membranes gives the oncotic pressure due to plasma proteins in the tissues. This pressure was −10.7 cmH2O.
Keywords: Tissue pressure, interstitial space, oncotic pressure, oncometer, inflammation
DOI: 10.3233/CH-1982-25-610
Journal: Clinical Hemorheology and Microcirculation, vol. 2, no. 5-6, pp. 511-522, 1982
IOS Press, Inc.
6751 Tepper Drive
Clifton, VA 20124
USA
Tel: +1 703 830 6300
Fax: +1 703 830 2300
[email protected]
For editorial issues, like the status of your submitted paper or proposals, write to [email protected]
IOS Press
Nieuwe Hemweg 6B
1013 BG Amsterdam
The Netherlands
Tel: +31 20 688 3355
Fax: +31 20 687 0091
[email protected]
For editorial issues, permissions, book requests, submissions and proceedings, contact the Amsterdam office [email protected]
Inspirees International (China Office)
Ciyunsi Beili 207(CapitaLand), Bld 1, 7-901
100025, Beijing
China
Free service line: 400 661 8717
Fax: +86 10 8446 7947
[email protected]
For editorial issues, like the status of your submitted paper or proposals, write to [email protected]
如果您在出版方面需要帮助或有任何建, 件至: [email protected]