Effects of long-term treatment with isoxsuprine on the blood viscosity profile in maturity-onset diabetics

Article type: Research Article

Authors: Bode, W.A. | Fonk, T. | van der Veen, E.A. | van der Meer, J.

Affiliations: Departments of Internal Medicine and Endocrinology, Free University Hospital, Amsterdam

Note: [] Accepted by: Editor H.H. Hartert

Abstract: A study was performed in fifteen patients with maturity-onset diabetes who had decreased erythrocyte flexibility as compared to controls. The patients were treated with isoxsuprine during 3 months. After this period only a reduction of blood viscosity at haematocrit 0.80 was found, indicating improved red cell flexibility. This might be explained by production of larger and more flexible erythrocytes.

Keywords: Blood viscosity, Erythrocyte flexibility, Diabetes mellitus, isoxsuprine therapy

DOI: 10.3233/CH-1982-2302

Journal: Clinical Hemorheology and Microcirculation, vol. 2, no. 3, pp. 189-193, 1982