Affiliations: [a] Pamukkale University, Medical Faculty, Department of Nuclear Medicine, Denizli, Turkey
| [b] Pamukkale University, Medical Faculty, Department of Physiology, Denizli, Turkey
| [c] Pamukkale University, Faculty of Medicine, Department of Biostatistics, Denizli, Turkey
Correspondence:
[*]
Corresponding author: Tarik Sengoz, Pamukkale University, Medical Faculty, Department of Nuclear Medicine,
Denizli, Turkey. Tel.: +9050528552305; E-mail: [email protected].
Abstract: BACKGROUND:Although radioiodine theraphy (RAIT) is thought to affect blood cells and oxidative stress, hemorheological alterations following dose-dependent RAIT remains unknown. OBJECTIVE:The aim of this study was to determine the effects of RAIT on hemorheological and oxidative stress parameters in patients with differentiated thyroid cancers (DTC). METHODS:Totally 31 DTC patients (mean age 46.32±11.15 years) and 26 healthy controls (mean age 50.50±6.22 years) were included. Venous blood samples were collected from each patient before and after treatment (7th day, 1th month and 6th month). Erythrocyte aggregation-deformability and oxidative stress parameters were determined. p < 0.05 was considered as statistically significant. RESULTS:Erythrocyte deformability of the patients determined at 16.87 and 30 Pascal were significantly lower than healthy individuals. Erythrocyte aggregation index (AI) of the patients was higher, whereas erythrocyte aggregation half-time (t½) was lower compared to control. Erythrocyte deformability values and AI were not significantly different from the pre- and post-radioiodine treatment groups. There was no statistically significant difference between the oxidative stress parameters before and after the treatment. CONCLUSIONS:Patients were in a worse hemorheological condition compared to healthy individuals. After RAIT, RBC deformability and aggregation were not affected and no significant change in oxidative stress parameters was detected.
