Affiliations: [a] Städtisches Klinikum Dresden, II. Medizinische Klinik, Dresden, Germany
| [b] Department of Biomaterials, Central Institute for Biomedical Technology, University of Ulm, Ulm, Germany
| [c] Department of Anesthesia, Pain Management and Perioperative Medicine, Faculty of Medicine, Dalhousie University, Halifax, Canada
| [d]
Fraunhofer Institute Applied Polymer Research (IAP), Division of Life Science and Bioprocesses, Department of Biomaterials and Healthcare, Potsdam-Golm, Germany
| [e] Institute of Clinical Haemostasiology and Transfusion Medicine, University of Saarland, Homburg, Germany
Correspondence:
[*]
Corresponding author: U. Gerk, Krankenhaus Dresden-Friedrichstadt, II. Medizinische Klinik, Dresden,
Germany. E-mail: [email protected].
Abstract: BACKGROUND: Contrast-induced acute kidney injury (CI-AKI), a potentially life-threatening complication of iodinated contrast media in patients with impaired renal function, has attracted increasing attention in recent years. There is overwhelming evidence that the most important pre-disposing factor for a contrast-medium induced nephropathy is the pre-existence of a renal impairment. METHODS: The registry was performed as a part of a quality management project in the Dresden-Friedrichstadt heart catheter laboratory. In compliance with the Declaration of Helsinki/Somerset West, 9,026 patients were included between 2010 and 2015. 100 patients of these were participants in a chronic dialysis program. All patients were dialyzed on the day before angiography. In all patients a coronary angiography, in 28 patients a stent implantation and in 12 patients a surgical reconstruction had to be performed. Prior to the intervention and one, two and three days thereafter the serum creatinine was measured. RESULTS: Up to the third day after application of the iodinated contrast medium no significant changes of the serum creatinine (baseline value: 423.3±42.6μmol/l) occurred (ANOVA for repeated measures: p = 0.507). On average, a slight decrease of the serum creatinine was found.All patients remained in their routine dialysis-program. 18 out of 100 died during the next three months after the procedure. CONCLUSION: The study revealed that the coronary angiography using Iodixanol as iodinated contrast medium did not result in an increase of serum creatinine, which was drastically elevated in these patients before application of the iodinated contrast medium.
