Aggregated time intensity curves after transarterial chemoembolization with degradable starch microspheres: A feasibility study
Issue title: Selected articles of the 32nd Annual Conference of the German Society for Clinical Hemorheology and Microcirculation, Dresden, Germany, 24 – 25 May, 2013
Affiliations: Department of Radiology, University Medical Center Regensburg, Regensburg, Germany
Note: [] Corresponding author: Philipp Wiggermann, Department of Radiology, University Medical Center Regensburg, Franz-Josef-Strauss-Allee 11, 93053 Regensburg, Germany. Tel.: +49 941 944 7401; Fax: +49 941 944 7402; E-mail: [email protected]
Abstract: PURPOSE: To evaluate tumor perfusion by means of dynamic contrast-enhanced ultrasonography (DCEUS) and aggregated time intensity curves (TICs) after transarterial chemoembolization with degradable starch microspheres (DSM-TACE). MATERIAL AND METHODS: 18 patients underwent 36 DCEUS examinations conducted via contrast agent application before and after DSM-TACE. Based on time intensity curves (TICs), we analyzed the microcirculation of the embolized HCC lesions with a dedicated perfusion software. RESULTS: Signal intensity was significantly reduced (p ≤ 0.001) after DSM-TACE at all time points measured. The mean signal intensity after 5, 10, 15, 20 and 25 s was 375.18 ± 16.41, 455.66 ± 17.92, 294.47 ± 19.91, 246.51 ± 20.99 and 173.45 ± 25.80 before TACE and 49.47 ± 2.43, 49.51 ± 2.40, 37.40 ± 2.45, 27.48 ± 2.65 and 27.96 ± 3.01 after TACE. CONCLUSION: In this study, tumor perfusion could be accurately evaluated by means of DCEUS and aggregated TICs after DSM-TACE.
