Enhancement of left ventricular function with isovolumetric hemodilution and glucose-insuline-KCI in the early phase of acute myocardial infarction in dogs
Affiliations: Department of Pathophysiology, Henan Medical University, Zhengzhou 450052, P.R. China
Abstract: The effect of isovolumetric hemodilution with dextran 40 and glucose-insuline-KCI (GIK) were evaluated on the left ventricular function (± dp/dt-max, left ventricular systolic pressure: LVSP) in dogs with acute myocardial infarction (AMI) during 6 hours. All animals were anesthetized, chest opened and ventilated with pure oxygen, The results were as follows. In the group of isovolumetric hemodilution or GIK infusion, +dp/dt-max increased as compared with that in the control group (no treatment was given after occlusion) (P<0.05), and the GIK infusion, came into effect later than the former. In the group of the combination of the ho therapies, LVSP and −dp/dt-max elevated as compared with those in either of the two groups, in each of which the animals were affected by only one therapy (P<0.05). The results indicated that both isovolumetric hemodilution with dextran 40 and GIK infusion significantly improve the left ventricular contractility in the early phase of AMI, that the GIK infusion took effect slowly, and that the combination of the two therapies could not only further improve the left ventricular contractility, but also enhance the relaxation significantly. It is demonstrated that the combination gives obvious coordinated effects.
