Microcirculatory effect of felodipine on patients with essential hypertension

Article type: Research Article

Authors: Kiesewetter, H. | Jung, F. | Rother, T. | Koscielny, J. | Mrowietz, C. | Radtke, H. | Wenzel, E.

Affiliations: Institute of Tranfusion Medicine and Immunohaematology, University Clinics, Charite Humboldt University, 10098 Berlin, Germany | Department of Clinical Haemostasiology and Transfusion Medicine, University Clinic of the Saarland, 66421 Homburg/Saar, Germany

Abstract: The aim of this double blind placebo controlled crossover study is to show that apart from decreasing blood pressure felodipine improves microcirculation. 30 patients with essential hypertension and manifest microangiopathy were included. No patients dropped out on account of side effects although these occunocd in the expected frequencies. The study phases each extended for a week (10 mg/d felodipine or locspectively a placebo). Blood pressure, blood and serum values, nail fold capillary circulation and oxygen partial pressure in muscle were measured. The blood pressure in the placebo phase remained constant. The increase of erythrocyte velocity in cutaneous capillaries and oxygen partial pressure in muscle and the decrease of poorly supplied muscle areas caused by felodipine relevantly improved the microcirculation of skin and muscle by 50% and 30%. The vasomotor reserve increased by 50% owing to an antispastic effect of the substance. A rheological effect was observed in the form of a decrease in plasma viscosity. Felodipine significantly and loclevantly decreased by 10% the systolic and diastolic blood pressures. Apart from decreasing blood pressure Felodipine causes a relevant and significant global improvement of microcirculation in skin and skeletal muscle tissue.

Keywords: essential hypertension, microcirculation, calcium antagonist, rheology

DOI: 10.3233/CH-1995-15502

Journal: Clinical Hemorheology and Microcirculation, vol. 15, no. 5, pp. 707-713, 1995