Affiliations: Department of Operative Techniques and Surgical Research, Institute of Surgery, University of Debrecen, Hungary | Department of Clinical Biochemistry and Molecular Pathology, Medical and Health Science Center, University of Debrecen, Hungary
Note: [] Corresponding author: Norbert Nemeth, MD, PhD, Department of Operative Techniques and Surgical Research, Medical and Health Science Centre, University of Debrecen, H-4032 Debrecen, Nagyerdei krt. 98, Hungary. Tel.:/Fax:+36 52 416 915; E-mail: [email protected]
Abstract: Growing number of clinical and experimental data reflect to the gender differences of hemorheological parameters. However, little is known about the potential hemorheological effect of gonadectomy and consequent changes in sex hormone concentration. Adult, same-aged male and female rats were involved in the study. In control male and female group no surgical intervention was performed. In gonadectomized (GoE) male and female groups bilateral orchidectomy or ovariectomy were completed. Body weight measurement and blood sampling were carried out in the 1st, 2nd and 3rd postoperative months. The GoE females had significant bodyweight augmentation and their plasma estrogen concentration decreased by 40–45% by the 1st postoperative month, while in males the testosterone level was not detectable after gonadectomy. Leukocyte and platelet counts moderately increased in GoE males. Elongation index values of erythrocytes slightly decreased in both genders after gonadectomy, showing converging values. Erythrocyte aggregation index values of GoE females significantly raised by the 2nd month. It can be concluded that gonadectomy in rats resulted in alteration (dominantly impairment) of blood microrheological parameters, by different manner in males and females. Supposedly decrease in estrogen can cause more expressed hemorheological changes than the cessation of testosterone.
Keywords: Gonadectomy, gender differences, laboratory animals, red blood cell aggregation, red blood cell deformability
