Affiliations: Inserm, UMR_S 763, CHU de Pointe-à-Pitre, Université des Antilles et de la Guyane, Pointe-à-Pitre, Guadeloupe | Université des Antilles et de la Guyane, Laboratoire ACTES UPRES-EA 3596, Département de Physiologie, Pointe-à-Pitre, Guadeloupe | Service d'Immunologie/Hématologie, Hôpital Bichat, AP-HP, Paris, France
Note: [] Corresponding author: Philippe Connes, PhD, Laboratoire ACTES (EA 3596), Département de Physiologie, UFR STAPS, Université des Antilles et de la Guyane Campus, de Fouillole, Pointe-à-Pitre Cedex, Guadeloupe. Tel.: +590 590 83 48 99; Fax: +590 590 83 05 13; E-mail: [email protected]
Abstract: Strenuous exercise is associated with an inflammatory response involving the activation of several types of blood cells. In order to document the specific activation of these cell types, we studied the effect of three maximal exercise tests conducted to exhaustion on the quantitative and qualitative pattern of circulating cell-derived microparticles and inflammatory molecules in healthy subjects. This study mainly indicated that the plasma concentration of microparticles from platelets and polymorphonuclear neutrophils (PMN) was increased immediately after the strenuous exercise. In addition, the increase in plasma concentration of microparticles from PMN and platelets was still observed after 2 hours of recovery. A similar pattern was observed for the IL-6 plasma level. In contrast, no change was observed for either soluble selectins or plasma concentration of microparticles from red blood cells, monocytes and endothelial cells. In agreement, sVCAM-1 and sICAM-1 levels were not changed by the exercise. We conclude that a strenuous exercise is accompanied by platelet- and PMN-derived microparticle production that probably reflects the activation of these two cell types.
