Quantitative expediency assessment of the zeta sedimentation ratio and the plasma viscosity in arterial hypertension research

Issue title: Selected Proceedings of the 14th European Conference for Clinical Hemorheology and Microcirculation, Dresden, Germany, June 27–30, 2007

Article type: Research Article

Authors: Stoeff, S.^; | Jovtchev, Sv. | Dikov, I. | Kolarov, D. | Galabova, T. | Trifonova, N. | Hadjieva, Sv. | Mladenova, A. | Lambreva, L. | Penev, M.

Affiliations: Department of Physics and Biophysics, Medical Faculty, Medical University Sofia, Sofia, Bulgaria | Department of Obstetrics and Gynaecology, Medical Faculty, Medical University Sofia, Sofia, Bulgaria | Department of Biology, Medical Faculty, Medical University Sofia, Sofia, Bulgaria | Department of Clinical Laboratory and Immunology, Medical Faculty, Medical University Sofia, Sofia, Bulgaria

Note: [] Corresponding author: Dr. Stilian Stoeff, Department Physics and Biophysics, Medical University Sofia, 2 Zdrave Street, 1431 Sofia, Bulgaria. E-mail: [email protected].

Abstract: Accepted methods of the ESR methodology (the Westergren mode and ZSR mode) and its alternative the plasma viscosity were tested for diagnostic utility in pregnancy induced hypertension and pre-eclampsia. The receiver-operating characteristic curve (ROC) analysis approved moderate diagnostic accuracy for the ESR methodology and supplied support for its preliminary estimated cutoff values but failed to indicate cogent discernment of pathology by values of plasma viscosity. Likely pathological whole blood alterations boost the erythrocyte aggregation while the concomitant depletion of macromolecules degrades plasma viscosity values.

Keywords: Pregnancy induced hypertension, ESR methodology, plasma viscosity, ROC analysis

DOI: 10.3233/CH-2008-1104

Journal: Clinical Hemorheology and Microcirculation, vol. 39, no. 1-4, pp. 381-384, 2008