Erythrocyte Ca²⁺ content and red cell membrane transverse fluidity gradient in a group of subjects with chronic renal failure (CRF)

Article type: Research Article

Authors: Caimi, Gregorio | Serra, Antonio | Vaccaro, Francesco | Lo Presti, Rosalia | Grifò, Giacomo | D'Asaro, Salvatrice | Picone, Francesco P. | Sarno, Antonio

Affiliations: Istituto di Clinica Medica e Malattie Cardiovascolari | Istituto di Patologia Chirurgica R, Università di Palermo, via del Vespro 129, 90127 Palermo - Italy

Abstract: In a group of stable CRF subjects, we evaluated the red cell membrane transverse fluidity gradient (obtained marking intact red blood cells with fatty acid fluorescent probes) and the total erythrocyte Ca2+ content. From the obtained results, it is evident that both these parameters discriminate the CRF subjects from normal controls. These data suggest an impairment of the erythrocyte rheology and metabolism in this disease.

Keywords: chronic renal failure, fluorescence spectroscopy, fatty acid probes

DOI: 10.3233/CH-1991-111-207

Journal: Clinical Hemorheology and Microcirculation, vol. 11, no. 1-2, pp. 49-54, 1991