Correlation between arterial mechanical properties, vascular biomaterial and tissue engineering
Issue title: Selected Papers from 1st Meeting on “Cardiovascular Biology: Endothelial Cell in Health and Hypertension”, 30 June–1 July 2006, Prague, Czech Republic
Affiliations: INSERM U684, Nancy, France | Henri Poincaré University, Nancy, France
Note: [] Corresponding author: Augustine Kakou, INSERM U684, Faculté de Médecine, 9 Avenue de la forêt de Haye, BP 184, 54505 Vandoeuvre les Nancy Cedex, France. Tel.: +33 3 83 68 36 23; Fax: +33 3 83 68 36 39; E-mail: [email protected]
Abstract: This review presents some of the recent technological developments in biomaterials used for the construction of synthetic cardiovascular vessels that are capable of simulating specific biological responses. However, with respect to the problems of stiffness, a major hypertensive risk factor, it is necessary to underline the important role of mechanical properties, such as vessel strength and composition, in vascular reconstructive surgery. Biomaterials occupy a central place in many cardiovascular disease treatments and they depend on the chemical nature of the polymers, on the biotechnology used, and also on cellular and gene therapy. Several methodologies using animal or human cells have emerged for constructing blood vessel replacements. Tissue-engineered blood vessel (TEBV) substitutes begin to motivate much work and have contributed to the restoration, maintenance, and/or improvement in tissue and organ function. Each methodology has it benefits, its promises, and holds many challenges in future biological, biomaterial and clinical research.
