Influence of hemorheological therapy on cardiac function after acute myocardial ischemia in rabbits

Article type: Research Article

Authors: Ying, Qi | Baisheng, Wang | Ning, Tang | Guangze, Li | Youtian, Huang

Affiliations: Department of Pathophysiology, Henan Medical University, Zhengzhou, China

Note: [] Accepted by: Editor F. Liao

Abstract: The improving effects of isovolemic hemodilution with crystal, colloidal solution and ligustrazine(LT) on the flow behavior of blood and cardiac function after acute myocardial ischemia were observed in 40 anesthetized rabbits. The results shc1wed that mere hemodilution significantly diminished the viscosity of plasma and whole blood(383/s), arid decreased fibrinogen. The left ventricular contractile function(+dp/dtmax and LVSP) was improved significantly, but diastolic function (-dp/dtmax and T values) wasn’t. The effect of hemodilution with colloidal solution on reducing fibrinogen was obvious. The use of LT based on hemodilution with colloidal solution significantly reduced the viscosity of plasma and whole blood at all shear rate, and fibrinogen. The cardiac contractile and diastolic functions were improved significantly. Physical internal circumstance wasn’t changed significantly with blood gas analysis in the whole experimental process. The results showed that hemodilution could improve the cardiac function after myocardial ischemia, but its effect was only confined to contractile function. The use of LT based on hemodilution could further improve the blood fluidity and overall cardiac function.

Keywords: Hemodilution, cardiac function test, ligustrazine

DOI: 10.3233/CH-1990-10206

Journal: Clinical Hemorheology and Microcirculation, vol. 10, no. 2, pp. 205-213, 1990