Effects of i.v. glycerol on some hemorheological parameters in patients with acute stroke

Article type: Research Article

Authors: Tonelli, Claudio^a | Catamo, Antonio^b | Molina, Enzo^a | Mombelloni, Andrea^a | Ponari, Oreste^a | Squeri, Manfredo^a | Tardio, Sergio^a

Affiliations: [a] IV Divisione Medica, Ospedale Regionale, Parma, Italy | [b] Istituto di Farmacologia, Universitá degli Studi, Parma, Italy

Note: [] Accepted by: Editor T. Di Perri

Abstract: In 18 subjects hospitalized for acute stroke were investigated the effects of 500 ml of glycerol infusion given daily for 3 days on hemorheological parameters. Whole blood and plasma viscosities were slightly but significantly reduced; peak effect occurred 2 hrs and 6 hrs respectively from the end of drug infusion; the same results were obtained after each administration. No changes were found on red cells filterability.

Keywords: glycerol, stroke, blood viscosity, plasma viscosity

DOI: 10.3233/CH-1990-10204

Journal: Clinical Hemorheology and Microcirculation, vol. 10, no. 2, pp. 185-189, 1990