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Issue title: A Selection of Papers from the International Symposium on Advanced Bio-Materials and Engineering '93 (ISABE '93)
Article type: Research Article
Authors: Kano, Seisuke | Yamazaki, Atsushi | Otsuka, Ryohei | Ohgaki, Masataka | Akao, Masaru | Aoki, Hideki
Affiliations: Materials Engineering Department, Mechanical Engineering Laboratory, AIST, 1-2 Namiki, Tsukuba-shi, Ibaraki 305, Japan | Department of Mineral Resources Engineering, School of Science and Engineering, Waseda University, 3-4-1 Ohkubo Shinjuku-ku, Tokyo 169, Japan | Institute for Medical and Dental Engineering, Tokyo Medical and Dental University, 2-3-10 Surugadai, Kanda, Chiyoda-ku, Tokyo 101, Japan
Abstract: The application of hydroxyapatite-sol as a drug carrier is being developed. Hydroxyapatite-sol which is a suspension consisting of hydroxyapatite nano-crystals, was synthesized using an ultrasonic homogenizer. The size of the crystals was 40 × 15 × 10 nm3 on average and their specific surface area was 100 m2/g. An amount of a glycoside antibiotics adsorbed onto hydroxyapatite nano-crystals was measured. The drug adsorbed 0.2 mg per 1 mg of hydroxyapatite. The affect of the drug adsorbed onto the hydroxyapatite was investigated using cancer cells. The drug, adsorbed onto the hydroxyapatite nano-crystals, inhibited cancer cell growth.
Keywords: hydroxyapatite-sol, drug carrier, nano-crystals
DOI: 10.3233/BME-1994-4404
Journal: Bio-Medical Materials and Engineering, vol. 4, no. 4, pp. 283-290, 1994
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