In this study a musculoskeletal model of driver steering maneuver was established. The model was driven by the steering angle and steering torque when performing typical steering test. The simulation was calculated using inverse dynamics. Maximum muscle activity and the muscle activity of each muscle were studied afterwards. The key muscles that generated steering torque were scapular portion of deltoid, infraspinatus, latissimus dorsi, subscapularis, triceps long head and triceps lateral head. Muscle co-contraction was analyzed quantitatively and was significantly different from muscle activity. This paper presents a preliminary research on the mechanical properties of upper limb muscles during steering maneuver. The results can serve as references for vehicle design and performance evaluation using the physiological characteristics of drivers.