Non-invasive model-based localization of ventricular ectopic centers from multichannel ECG

Issue title: OIPE 2008

Article type: Research Article

Authors: Farina, Dmytro^{a; *} | Dössel, Olaf^b

Affiliations: [a] CST AG, Darmstadt, Germany | [b] Institute of Biomedical Engineering, University of Karlsruhe (TH), Karlsruhe, Germany

Correspondence: [*] Corresponding author: CST AG, Bad Nauheimer Str. 19, 64289 Darmstadt, Germany. Tel.: +49 6151/73030; E-mail: [email protected]

Abstract: Non-invasive localization of premature ventricular beat (PVB) foci is very important for medical treatment of numerous cardiac diseases. In this work a model-based method of reconstruction of ectopic center locations is investigated. Within the scope of this method patient's multichannel ECG is used as a reference for optimization of an electrophysiological cardiac model. This model is based on the cellular automaton principle and utilizes anatomical data of the patient. Optimized are coordinates of the ectopic focus as well as excitation conduction velocity of ventricular myocardium. Initial values for these parameters are obtained by solving the linearized problem of electrocardiography in terms of activation times. Optimization is performed by minimization of discrepancy between the simulated and reference ECGs. The aim of the current work is to estimate the quality of ectopic focus localization delivered by this method. Four sample ectopic beats have been simulated, with their foci located in different regions of the left ventricle. 1% Gaussian noise has been introduced into the resulting ECGs. In this way the "measured" ECG signals for this investigation have been obtained. Afterwards the origin of each ectopic beat has been reconstructed using the model-based approach. The method has demonstrated reliable localization of PVB foci, reconstruction errors have not exceeded 6.1 mm.

Keywords: Ectopic beats, inverse problem of electrocardiography, cardiac modeling

DOI: 10.3233/JAE-2009-1029

Journal: International Journal of Applied Electromagnetics and Mechanics, vol. 30, no. 3-4, pp. 289-297, 2009