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Issue title: Machine Learning in Bioinformatics
Article type: Research Article
Authors: Cilia, Elisa | Landwehr, Niels | Passerini, Andrea
Affiliations: Département d'Informatique, Université Libre de Bruxelles, Belgium. [email protected] | Department of Computer Science, University of Potsdam, Germany. [email protected] | Dipartimento di Ingegneria e Scienza dell'Informazione, University of Trento, Italy. [email protected]
Note: [] Address for correspondence: Département d'Informatique, Université Libre de Bruxelles, Belgium This work was done while she was at Dipartimento di Ingegneria e Scienza dell'Informazione, University of Trento, Italy
Abstract: We introduce hierarchical kFOIL as a simple extension of the multitask kFOIL learning algorithm. The algorithm first learns a core logic representation common to all tasks, and then refines it by specialization on a per-task basis. The approach can be easily generalized to a deeper hierarchy of tasks. A task clustering algorithm is also proposed in order to automatically generate the task hierarchy. The approach is validated on problems of drug-resistance mutation prediction and protein structural classification. Experimental results show the advantage of the hierarchical version over both single and multi task alternatives and its potential usefulness in providing explanatory features for the domain. Task clustering allows to further improve performance when a deeper hierarchy is considered.
DOI: 10.3233/FI-2011-604
Journal: Fundamenta Informaticae, vol. 113, no. 2, pp. 151-177, 2011
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