NeuroRehabilitation - Volume 54, issue 1

Authors: Schnakers, Caroline | Zasler, Nathan D.

Article Type: Editorial

DOI: 10.3233/NRE-246000

Citation: NeuroRehabilitation, vol. 54, no. 1, pp. 1-1, 2024

Authors: Robbins MD, Nathaniel M. | Bernat MD, James L.

Article Type: Research Article

Abstract: The current classification scheme for severe disorders of consciousness (DoC) has several shortcomings. First, there is no consensus on how to incorporate patients with covert consciousness. Second, there is a mismatch between the definitions of severe DoC, based on consciousness, and the diagnosis of these same DoC, which is based on observable motoric responsiveness. Third, current categories are grouped into large heterogeneous syndromes which share phenotype, but do not incorporate underlying pathophysiology. Here we discuss several ethical issues pertaining to the current nosology of severe DoC. We conclude by proposing a revised nosology which addresses these shortcomings.

Keywords: Consciousness, coma, unresponsiveness, vegetative state, minimally conscious state, nosology

DOI: 10.3233/NRE-230120

Citation: NeuroRehabilitation, vol. 54, no. 1, pp. 3-9, 2024

Authors: Schnakers, Caroline

Article Type: Research Article

Abstract: Detecting willful cognition in these patients is known to be challenging due to the patients’ motor disabilities and high vigilance fluctuations but also due to the lack of expertise and use of adequate tools to assess these patients in specific settings. This review will discuss the main disorders of consciousness after severe brain injury, how to assess consciousness and cognition in these patients, as well as the challenges and tools available to overcome these challenges and reach an accurate diagnosis.

Keywords: Brain injury, consciousness, coma, vegetative state, unresponsive wakefulness syndrome, minimally conscious state, behavioral assessment

DOI: 10.3233/NRE-230140

Citation: NeuroRehabilitation, vol. 54, no. 1, pp. 11-21, 2024

Authors: Young, Michael J. | Edlow, Brian L. | Bodien, Yelena G.

Article Type: Research Article

Abstract: Covert consciousness is a state of residual awareness following severe brain injury or neurological disorder that evades routine bedside behavioral detection. Patients with covert consciousness have preserved awareness but are incapable of self-expression through ordinary means of behavior or communication. Growing recognition of the limitations of bedside neurobehavioral examination in reliably detecting consciousness, along with advances in neurotechnologies capable of detecting brain states or subtle signs indicative of consciousness not discernible by routine examination, carry promise to transform approaches to classifying, diagnosing, prognosticating and treating disorders of consciousness. Here we describe and critically evaluate the evolving clinical category of covert …consciousness, including approaches to its diagnosis through neuroimaging, electrophysiology, and novel behavioral tools, its prognostic relevance, and open questions pertaining to optimal clinical management of patients with covert consciousness recovering from severe brain injury. Show more

Keywords: Coma, cognitive motor dissociation, vegetative state, unresponsive wakefulness syndrome, covert consciousness, fMRI, EEG, minimally conscious state

DOI: 10.3233/NRE-230123

Citation: NeuroRehabilitation, vol. 54, no. 1, pp. 23-42, 2024

Authors: Russell, Mary E. | Hammond, Flora M. | Murtaugh, Brooke

Article Type: Research Article

Abstract: Disorders of consciousness after severe brain injury encompass conditions of coma, vegetative state/unresponsive wakefulness syndrome, and minimally conscious state. DoC clinical presentation pose perplexing challenges to medical professionals, researchers, and families alike. The outcome is uncertain in the first weeks to months after a brain injury, with families and medical providers often making important decisions that require certainty. Prognostication for individuals with these conditions has been the subject of intense scientific investigation that continues to strive for valid prognostic indicators and algorithms for predicting recovery of consciousness. This manuscript aims to provide an overview of the current clinical landscape surrounding …prognosis and optimizing recovery in DoC and the current and future research that could improve prognostic accuracy after severe brain injury. Improved understanding of these factors will aid healthcare professionals in providing optimal care, fostering hope, and advocating for ethical practices in the management of individuals with DoC. Show more

Keywords: Disorders of consciousness, DoC, brain injury, TBI, recovery, prognosis, neuroplasticity

DOI: 10.3233/NRE-230148

Citation: NeuroRehabilitation, vol. 54, no. 1, pp. 43-59, 2024

Authors: Estraneo, Anna | Briand, Marie-Michele | Noé, Enrique

Article Type: Review Article

Abstract: BACKGROUND: A few studies specifically addressed medical comorbidities (MCs) in patients with severe acquired traumatic or non-traumatic brain injury and prolonged disorders of consciousness (pDoC; i.e., patients in vegetative state/unresponsive wakefulness syndrome, VS/UWS, or in minimally conscious state, MCS). OBJECTIVE: To provide an overview on incidence of MCs in patients with pDoC. METHODS: Narrative review on most impacting MCs in patients with pDoC, both those directly related to brain damage (epilepsy, neurosurgical complications, spasticity, paroxysmal sympathetic hyperactivity, PSH), and those related to severe disability and prolonged immobility (respiratory comorbidities, endocrine disorders, metabolic abnormalities, …heterotopic ossifications). RESULTS: Patients with pDoC are at high risk to develop at least one MC. Moderate or severe respiratory and musculoskeletal comorbidities are the most common MCs. Epilepsy and PSH seem to be more frequent in patients in VS/UWS compared to patients in MCS, likely because of higher severity in the brain damage in VS. Endocrine metabolic, PSH and respiratory complications are less frequent in traumatic etiology, whereas neurogenic heterotopic ossifications are more frequent in traumatic etiology. Spasticity did not significantly differ between VS/UWS and MCS and in the three etiologies. MCs are associated with higher mortality rates, worse clinical improvement and can impact accuracy in the clinical diagnosis. CONCLUSIONS: The frequent occurrence of several MCs requires a specialized rehabilitative setting with high level of multidisciplinary medical expertise to prevent, appropriately recognize and treat them. Comprehensive rehabilitation could avoid possible progression to more serious complications that can negatively impact clinical outcomes. Show more

Keywords: Disorders of consciousness, medical comorbidities, outcome, rehabilitation setting

DOI: 10.3233/NRE-230130

Citation: NeuroRehabilitation, vol. 54, no. 1, pp. 61-73, 2024

Authors: Thibaut, Aurore | Aloisi, Marta | Dreessen, Joëlle | Alnagger, Naji | Lejeune, Nicolas | Formisano, Rita

Article Type: Review Article

Abstract: BACKGROUND: Following a severe acquired brain injury, neuro-orthopaedic disorders are commonplace. While these disorders can impact patients’ functional recovery and quality of life, little is known regarding the assessment, management and treatment of neuro-orthopaedic disorders in patients with disorders of consciousness (DoC). OBJECTIVE: To describe neuro-orthopaedic disorders in the context of DoC and provide insights on their management and treatment. METHODS: A review of the literature was conducted focusing on neuro-orthopaedic disorders in patients with prolonged DoC. RESULTS: Few studies have investigated the prevalence of spastic paresis in patients with prolonged DoC, which is …extremely high, as well as its correlation with pain. Pilot studies exploring the effects of pharmacological treatments and physical therapy show encouraging results yet have limited efficacy. Other neuro-orthopaedic disorders, such as heterotopic ossification, are still poorly investigated. CONCLUSION: The literature of neuro-orthopaedic disorders in patients with prolonged DoC remains scarce, mainly focusing on spastic paresis. We recommend treating neuro-orthopaedic disorders in their early phases to prevent complications such as pain and improve patients’ recovery. Additionally, this approach could enhance patients’ ability to behaviourally demonstrate signs of consciousness, especially in the context of covert awareness. Show more

Keywords: Coma, spasticity, rehabilitation, motor function, traumatic brain injury, vegetative state, minimally conscious state

DOI: 10.3233/NRE-230137

Citation: NeuroRehabilitation, vol. 54, no. 1, pp. 75-90, 2024

Authors: Regnier, Amandine | Mélotte, Evelyne | Aubinet, Charlène | Alnagger, Naji | Fischer, David | Lagier, Aude | Thibaut, Aurore | Laureys, Steven | Kaux, Jean-François | Gosseries, Olivia

Article Type: Research Article

Abstract: Following severe brain injuries, a subset of patients may remain in an altered state of consciousness; most of these patients require artificial feeding. Currently, a functional oral phase and the presence of exclusive oral feeding may constitute signs of consciousness. Additionally, the presence of pharyngo-laryngeal secretions, saliva aspiration, cough reflex and tracheostomy are related to the level of consciousness. However, the link between swallowing and consciousness is yet to be fully understood. The primary aim of this review is to establish a comprehensive overview of the relationship between an individual’s conscious behaviour and swallowing (reflexive and voluntary). Previous studies of …brain activation during volitional and non-volitional swallowing tasks in healthy subjects are also reviewed. We demonstrate that the areas activated by voluntary swallowing tasks (primary sensorimotor, cingulate, insula, premotor, supplementary motor, cerebellum, and operculum) are not specific to deglutitive function but are shared with other motor tasks and brain networks involved in consciousness. This review also outlines suitable assessment and treatment methods for dysphagic patients with disorders of consciousness. Finally, we propose that markers of swallowing could contribute to the development of novel diagnostic guidelines for patients with disorders of consciousness. Show more

Keywords: Deglutition, deglutition disorders, dysphagia, consciousness disorders, neuroimaging, speech therapy

DOI: 10.3233/NRE-230135

Citation: NeuroRehabilitation, vol. 54, no. 1, pp. 91-107, 2024

Authors: Murtaugh, Brooke | Morrissey, Ann-Marie | Fager, Susan | Knight, Heather E. | Rushing, Jess | Weaver, Jennifer

Article Type: Review Article

Abstract: BACKGROUND: Current clinical guidelines recommend that a multidisciplinary team inclusive of allied healthcare practitioners deliver assessment and intervention for disorders of consciousness. Allied health professionals include music, occupational, physical, and speech therapists. These allied health clinicians are challenged to select interventions due to a lack of evidence-based recommendations regarding rehabilitation interventions that support recovery of consciousness. This umbrella review synthesizes available systematic reviews (SRs) that describe occupational, speech and language, physical and/or musical therapeutic interventions for people with disorders of consciousness. OBJECTIVES: Identify and summarize evidence from systematic reviews (SRs) that examine allied healthcare interventions for …patients with disorders of consciousness. Additionally, this umbrella review aims to evaluate the impact of allied health interventions on recovery of consciousness, methodological quality and risk of bias for the included systematic reviews. METHODS: An umbrella review was completed. The review was reported according to the Preferred Reporting Items for Overview of Reviews (PRIOR) guidance. Five academic databases (PubMed, CINAHL, PsycInfo, Web of Science, and the Cochrane Library) were searched for SRs and/or meta-analyses of allied health (i.e., music, occupational, physical, and speech therapy) interventions for disorders of consciousness. For included studies, data were extracted and quality of the SRs appraised using the A Measurement Tool to Assess Systematic Reviews (AMSTAR) 2 checklist. Data extracted from each SR identified the authors and years of primary studies, interventions, comparators, and outcomes related to recovery of consciousness (i.e., neurobehavioral/cognitive), functional status, physiological response pain, and adverse events. Rehabilitation interventions were categorized and described. RESULTS: Fifteen SRs were included and three of these reviews conducted meta-analyses. Identified rehabilitation interventions included: 1) sensory stimulation, 2) median nerve stimulation, 3) communication/environmental control through assistive technology, 4) mobilization, and 5) music-based therapy. SRs were published between 2002 and 2022 and included 2286 participants. Using the AMSTAR 2, the quality of reviews was critically low (k  = 6), low (k  = 3), moderate (k  = 4), and high (k  = 2). SRs within this umbrella review demonstrated significant heterogeneity in research methods and use of outcome measures to evaluate the recovery of consciousness within the primary studies. These factors influenced the ability to conduct meta-analyses. CONCLUSIONS: Sensory stimulation, median nerve stimulation, music therapy and mobilization are all interventions that demonstrate some level of benefit, but current SRs fail to prove benefit through high-level quality evidence. There is an indisputable need for continued rehabilitation research to expand options for treatment modalities and to ensure that the interventions being applied to DoC rehabilitation are evidence-based to improve consciousness and recovery. Show more

Keywords: Consciousness disorders, rehabilitation, systematic review, allied health, brain injury

DOI: 10.3233/NRE-230149

Citation: NeuroRehabilitation, vol. 54, no. 1, pp. 109-127, 2024

Authors: Slomine, Beth | Molteni, Erika

Article Type: Research Article

Abstract: Pediatric disorders of consciousness (PedDOC) encompass conditions that may occur following very severe traumatic or other forms of acquired brain injury sustained during childhood. As in adults, PedDOC is described as a disturbance of awareness and/or responsiveness. PedDOC is a complex condition that requires specialized care, infrastructures, and technologies. PedDOC poses many challenges to healthcare providers and caregivers during recovery and throughout development. In this commentary, we intend to highlight some considerations, controversies, and caveats on the diagnosis, prognosis and treatment of PedDOC.

Keywords: Pediatrics, disorders of consciousness, minimally conscious state, vegetative state, coma, brain injury

DOI: 10.3233/NRE-230131

Citation: NeuroRehabilitation, vol. 54, no. 1, pp. 129-139, 2024

Authors: Fins, Joseph J. | Shulman, Kaiulani S. | Wright, Megan S. | Shapiro, Zachary E.

Article Type: Research Article

Abstract: It is helpful to think about the needs of patients with moderate to severe brain injury through the lens of disability law. However, there are limitations to current disability law that contribute to ongoing segregation and marginalization of individuals with severe brain injury. Indeed, one of the paradoxes of American jurisprudence is that more clear constitutional protections accrue to those who have definitively immutable conditions. Thus, as neuroscience brings new therapies to those with brain injury, they may become less protected by the constitutional elements of disability law because their conditions have changed and become mutable . This is the …clinical progress that brain injury professionals all seek to achieve, but ironically these advances could potentially degrade the legal protections of patients who benefit from emerging treatments. In this paper, we will critically examine this paradox at the interface of medicine and the law and suggest that the Americans with Disabilities Act (ADA) could be nicely complemented by legislation we have named the Americans with Abilities Act (AWAA). Instead of focusing on disabilities that need protection, the AWAA seeks to sustain and foster newfound abilities made possible by the fruits of medicine and neuroscience. Show more

Keywords: Brain injury, neuroethics, disability law, Americans with Abilities Act, assisted living, vegetative state

DOI: 10.3233/NRE-230118

Citation: NeuroRehabilitation, vol. 54, no. 1, pp. 141-147, 2024

Authors: Zasler, Nathan D.

Article Type: Research Article

Abstract: BACKGROUND: The tasks and responsibilities that come with clinician involvement in medicolegal proceedings can be daunting and particularly so in challenging areas such as provision of medicolegal opinions in cases involving disorders of consciousness (DoC). OBJECTIVE: The aim of this narrative review was to provide education and advice to healthcare practitioners who by choice or circumstance are asked and/or required to provide medicolegal opinions in cases involving patients with DoC. METHODS: A literature search was conducted using PubMed Central and MedlinePlus for articles dealing with clinician involvement in medicolegal cases involving persons with …DoC. The information provided also integrates the authors’ nearly 40 years of clinical experience, brain injury medicine practice and “trials and tribulations” associated with medicolegal involvement in such cases. RESULTS: The literature was found to be replete with articles on brain death and withdrawal/withholding of care (which are not the focus of this review). The extant medical literature in brain injury medicine on the other hand is currently lacking in practical information for clinicians working “in the trenches” regarding the challenges and caveats of medicolegal involvement in such cases. CONCLUSION: This review provides the reader with a big picture overview of the most pertinent medicolegal topics inherent in clinical work with patients with DOC including pertinent nomenclature, caveats regarding forensic consultation including independent medical examinations, testimony tips, discussion of life expectancy/median survival concepts, prognostication in a medicolegal context, documentation and record keeping as well as some of the specific challenges pertinent to these types of brain injury cases that are not per se relevant in less severe injuries. Show more

Keywords: Medicolegal, legal, independent medical evaluation, brain injury, disorder of consciousness

DOI: 10.3233/NRE-230242

Citation: NeuroRehabilitation, vol. 54, no. 1, pp. 149-165, 2024

Authors: Chan, Soo Chin | Engkasan, Julia Patrick

Article Type: Other

Abstract: BACKGROUND: Stroke can lead to permanent and severe disability. Provision of information to stroke survivors and their carers could help them cope with consequences of stroke and aware of secondary prevention. OBJECTIVE: The aim of this Cochrane review was to assess the effects of active or passive information provision for stroke survivors or their carers. METHODS: The population addressed in this review included stroke survivors, their carers, or both. The intervention studied was provision of active or passive information compared to standard care or where information and another therapy were compared with the …other therapy alone, or where the comparison was between active and passive information provision. The primary outcomes were knowledge about stroke and stroke services, and anxiety. CONCLUSIONS: The authors concluded that the active provision of information may improve stroke survivors stroke-related knowledge and quality of life. It may reduce the cases and symptoms of anxiety and probably depression. The effect of active information provision to carers and passive information provision is still unclear; however, passive information may worsen stroke patients’ symptoms of anxiety and depression. Show more

Keywords: Information, stroke survivors, carers, rehabilitation

DOI: 10.3233/NRE-246001

Citation: NeuroRehabilitation, vol. 54, no. 1, pp. 167-169, 2024