International Journal of Risk & Safety in Medicine - Volume 2, issue 1 - Journals

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Risk and safety in radiography in women of childbearing ability

Authors: Pearson, Ruth H.

Article Type: Research Article

DOI: 10.3233/JRS-1991-2101

Citation: International Journal of Risk and Safety in Medicine, vol. 2, no. 1, pp. 1-6, 1991

Price: EUR 27.50

Ethics in the pharmaceutical industry: acceptance of responsibility or a facet of marketing?

Authors: Chirac, Pierre

Article Type: Other

DOI: 10.3233/JRS-1991-2102

Citation: International Journal of Risk and Safety in Medicine, vol. 2, no. 1, pp. 7-9, 1991

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Concomitant drug use among patients on cardiac glycosides

Authors: Leufkens, Hubert G. | Herings, Ron M.C. | Kollöffel, Willemien J. | Bakker, Albert

Article Type: Research Article

Abstract: Cardiac glycosides are among the drugs most commonly used in elderly patients and constitute approximately 3% of all prescriptions filled by these patients. Recipients of digitalis usually show high levels of concomitant drug use. In this study 1,128 users of cardiac glycosides users were matched 1:1 by age, gender and community to non-users. Concomitant drug use patterns in the users group were compared with such patterns in the non-users group. Utilization data were drawn from a sample of pharmacy records (population size: n=74,445). Digoxin accounted for 99% of all digitalis prescriptions. Digoxin use seems to be an important predictor for …high morbidity levels and consequent drug use. The prevalence of use of anticoagulants, thyroid drugs, anti-diarrheals, anti-diabetics, anti-hypertensives and diuretics was 2–4 times higher in the digitalis group. Concomitant drug use patterns in naturally occurring groups of patients may provide an important source of information on the health status of recipients of digoxin. Show more

Keywords: Cardiac glycosides, Cardiovascular diseases, Concomitant drug use, Drug utilization, Pharmacoepidemiology, Matched-pairs

DOI: 10.3233/JRS-1991-2103

Citation: International Journal of Risk and Safety in Medicine, vol. 2, no. 1, pp. 11-20, 1991

Price: EUR 27.50

Prevention of adverse reactions to intravascular contrast media

Authors: Soyer, Ph. | Levesque, M. | Rouleau, Ph.

Article Type: Research Article

Abstract: The exact mechanisms of adverse reactions to contrast media are still imperfectly known; they may, however, be idiosyncratic or non-idiosyncratic. Non-idiosyncratic reactions can be prevented by using new non-ionic contrast agents. Idiosyncratic reactions can be prevented by specific premedication. Patients with a history of idiosyncratic reactions may benefit from prophylactic administration of corticosteroids and antihistamines. Patients who seem more likely than others to react to contrast media must be premedicated, the risk of a reaction being detected and evaluated by questioning. It has recently been suggested that all patients about to receive an intravascular injection of contrast medium should also …be premedicated. Show more

Keywords: Radiology, Contrast media, Adverse reactions, Prevention, Premedication

DOI: 10.3233/JRS-1991-2104

Citation: International Journal of Risk and Safety in Medicine, vol. 2, no. 1, pp. 21-27, 1991

Price: EUR 27.50

Drugs after 1992; an equation with many remaining unknowns

Authors: Boer, E.J.

Article Type: Other

Abstract: Editorial Note: The weekly medical journal of The Netherlands – the Nederlands Tijdschrift Door Geneeskunde – has for many years periodically sponsored expert meetings to consider medical topics of current importance. On June 15th 1990, the Journal held a conference on the situation created by the promised common market for pharmaceutical products which is to be created by the European Community. The views expressed there represented professional reactions in one member state to a development which has been motivated by international economic interests rather than considerations of health or medical care. The report which follows appears simultaneously in Dutch …in The Netherlands (Ned Tijdschr Geneesk 1990; 134, Nr. 38). Show more

DOI: 10.3233/JRS-1991-2105

Citation: International Journal of Risk and Safety in Medicine, vol. 2, no. 1, pp. 29-37, 1991

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Detecting adverse drug reactions – a concise update

Authors: Lawson, D.H.

Article Type: Research Article

Abstract: Editorial Note: In the three decades which have passed since the need for more thorough studies of the side effects of pharmaceuticals was thrown into sharp profile by the thalidomide disaster, much has changed in the way in which these unwanted effects of drugs are approached and the extent to which they are understood. The three papers which follow in this issue open a series which seeks to provide a concise update of each of the principal methods which underlie the science and art of adverse reaction study. The papers were presented at a closed meeting jointly organized by …the European Regional Office of the World Health Organization and the W.H.O. Collaborating Centre for Public Health Research, Kiel, Germany, on 26–29 November 1990, under the Chairmanship of Prof. Fritz Beske. The series will continue in future issues of the Journal. Show more

Keywords: Pharmaceuticals, Adverse reactions, Clinical studies, Methodology

DOI: 10.3233/JRS-1991-2106

Citation: International Journal of Risk and Safety in Medicine, vol. 2, no. 1, pp. 39-44, 1991

Price: EUR 27.50