Searching for just a few words should be enough to get started. If you need to make more complex queries, use the tips below to guide you.
Issue title: Selected papers from the Heating by Electromagnetic Sources Conference 2016 (HES-2016)
Guest editors: Paolo Di Barba, Fabrizio Dughiero, Michele Forzan and Elisabetta Sieni
Article type: Research Article
Authors: Ruggiero, M. Rosariaa; b; * | Geninatti Crich, Simonettaa | Sieni, Elisabettac | Sgarbossa, Paoloc | Cavallari, E.a | Stefania, Rachelea | Dughiero, Fabrizioc | Aime, Silvioa
Affiliations: [a] Department of Molecular Biotechnology and Health Sciences, University of Turin, Turin, Italy | [b] Department of Industrial Engineering, University of Padua, Padua, Italy | [c] SAET S.p.A- Leinì (To) Italy
Correspondence: [*] Corresponding author: M. Rosaria Ruggiero, Department of Molecular Biotechnology and Health Sciences, University of Turin, Turin, Italy. E-mail:ruggiero.mr@gmail.com
Abstract: Recently, nanoscale stimuli-responsive devices have received much attention thanks to their potential to limit the cytotoxic effect of the therapeutic treatment at the diseased tissue. Among different physical triggers, large alternating magnetic fields enable the conversion of magnetic energy into heat by using magnetic nanoparticles that generate localized hyperthermia, named Magneto Fluid Hyperthermia (MFH). This methodology can be exploited for cancer therapy or/and thermally activated drug release. The small size iron oxide nanoparticles (Fe-NPs), such as SPIO (small iron oxide particles) and USPIO (ultra-small iron oxide particles), currently used for this application have many limitations due to their 1) high intratumor concentration needed due to the low heating power 2) short particle blood-half-life, 3) non-specific distribution, 4) low internalization efficiency. For these reasons many efforts are necessary to make magneto fluid particle hyperthermia (MFH) a competitive tumor therapy for clinical applications. New iron oxide nanoparticles, coated with oleate, with a diameter of 5-18 nm, have been prepared by co-precipitation and incorporated into PLGA-NPs (PLGA=Poly(lactic-co-glycolic acid) in order to improve their biocompatibility and ``in vivo'' stability. Moreover, PLGA-NPs have been loaded with both NPs-Fe and antitumor drugs (Paclitaxel, PTX), an anticancer hydrophobic drug used in the treatment of ovarian and breast cancer, to perform MFH triggered drug release. The PTX and Fe-NPs loaded nanoparticles may be considered as an effective anticancer drug delivery system for Imaging-guided hyperthermic treatment of tumors.
Keywords: Magnetic fluid hyperthermia, iron oxide particles, poly lactic and glycolic acid, nuclear magnetic resonance, paclitaxel
DOI: 10.3233/JAE-162246
Journal: International Journal of Applied Electromagnetics and Mechanics, vol. 53, no. S1, pp. S53-S60, 2017
IOS Press, Inc.
6751 Tepper Drive
Clifton, VA 20124
USA
Tel: +1 703 830 6300
Fax: +1 703 830 2300
sales@iospress.com
IOS Press c/o Accucoms US, Inc.
For North America Sales and Customer
Service
West Point Commons
1816 West Point Pike
Suite 125
Lansdale, PA 19446
USA
Tel: +1 215 393 5026
Fax: +1 215 660 5042
iospress@accucoms.com
For editorial issues, like the status of your submitted paper or proposals, write to editorial@iospress.nl
IOS Press
Nieuwe Hemweg 6B
1013 BG Amsterdam
The Netherlands
Tel: +31 20 688 3355
Fax: +31 20 687 0091
info@iospress.nl
IOS Press - c/o Accucoms Europe
Leiden
The Netherlands
Tel: +31 88 4100 400
Fax: +31 88 4100 401
iospress@accucoms.com
For editorial issues, permissions, book requests, submissions and proceedings, contact the Amsterdam office:
+31 20 6883355
info@iospress.nl
Inspirees International (China Office)
Ciyunsi Beili 207(CapitaLand), Bld 1, 7-901
100025, Beijing
China
Free service line: 400 661 8717
For editorial issues, like the status of your submitted paper or proposals, write to editorial@iospress.nl
如果您在出版方面需要帮助或有任何建, 件至: editorial@iospress.nl
Fax: +86 10 8446 7947
china@iospress.cn
IOS Press
c/o Ohmsha, Ltd.
3-1 Kanda Nishiki-cho
Chiyoda-ku
Tokyo 101
Japan
Tel.: +81 3 3233 0641
Fax: +81 3 3233 6224
chokuhan@ohmsha.co.jp