Affiliations: [a] Department of Mathematics, University of Innsbruck, Innsbruck, Austria | [b] Institute of Electrical and Biomedical Engineering, Medical Informatics and Technology (UMIT), Private University for Health Sciences, Tirol, Austria | [c] Institute of Biomedical Engineering and Informatics, Technische Universität Ilmenau, Ilmenau, Germany
Correspondence:
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Corresponding author: Markus Haltmeier, Department of Mathematics, University of Innsbruck, Technikerstrasse 13, Innsbruck, Austria. E-mail: [email protected]
Abstract: Magnetorelaxometry imaging is a novel tool for quantitative determination of the spatial distribution of magnetic nanoparticle inside an organism. The use of multiple excitation patterns has been demonstrated to significantly improve spatial resolution. However, increasing the number of excitation patterns is considerably more time consuming, because several sequential measurements have to be performed. In this paper, we use compressed sensing in combination with sparse recovery to reduce the total measurement time and to improve spatial resolution. For image reconstruction, we propose using the Douglas-Rachford splitting algorithm applied to the sparse Tikhonov functional including a positivity constraint. Our numerical experiments demonstrate that the resulting algorithm is capable to accurately recover the magnetic nanoparticle distribution from a small number of activation patterns. For example, our algorithm applied with 10 activations yields half the reconstruction error of quadratic Tikhonov regularization applied with 50 activations, for a tumor-like phantom.
