Source space localization technique for Magnetoencephalography (MEG) source reconstruction

Article type: Research Article

Authors: Im, Chang Hwan^{a; *} | Jung, Hyun Kyo^a | Lee, Yong Ho^b | Kwon, Hyuk Chan^b

Affiliations: [a] School of Electrical Engineering (ENG420-040), Seoul National University, San 56-1, Shillim-dong, Kwanak-gu, 151-742, Seoul, Korea | [b] Korea Research Institute of Standards and Science (KRISS), Daejeon, Korea

Correspondence: [*] Corresponding author. Tel.: +82 2 880 7262; Fax: +82 2 878 1452; E-mail: [email protected]

Abstract: Magnetoencephalography (MEG) source reconstruction problems suffer from their own ill-posed characteristics, especially when a cortically distributed source model is used. This is because many variables have to be determined using small amounts of measured data, and this leads to a large computational cost. In this paper, a very efficient method is proposed to localize the source space effectively. A Fourier based 3-dimensional spatial function approximates the spatial distribution of the current dipole moments. The coefficients of the function are determined using the sensitivity analysis employing the steepest decent updating scheme. By repeatedly applying the method to smaller and smaller domains, a reduced source space, which includes the small number of variables, can be obtained. By applying this method to a real brain model, its usefulness was verified.

Keywords: function approximation, inverse problem, magnetoencephalography (MEG), sensitivity analysis

DOI: 10.3233/JAE-2004-295

Journal: International Journal of Applied Electromagnetics and Mechanics, vol. 20, no. 1, pp. 29-36, 2004