Optimal control of a model for brain lactate kinetics

Article type: Research Article

Authors: Raad, Hussein^a | Cherfils, Laurence^{a; *} | Allery, Cyrille^a | Guillevin, Rémy^{b; c}

Affiliations: [a] Laboratoire des Sciences de l’Ingénieur pour l’Environnement (LaSIE), UMR CNRS 7356, La Rochelle Université, Avenue Michel Crépeau F-17042 La Rochelle Cedex 1, France | [b] Laboratoire I3M et Laboratoire de Mathématiques et Applications, University of Poitiers, 11 Boulevard Marie et Pierre Curie, 86073 Poitiers cedex 9, France | [c] CHU de Poitiers, 2 rue de la Milétrie, 86000 Poitiers, France

Correspondence: [*] Corresponding author. E-mail: [email protected].

Abstract: The aim of this paper is to first study a Cahn-Hilliard model for brain lactate kinetics with a control function. This control allows for optimal treatment administered to ill patients suffering from glioma, in order to reduce their brain lactate concentrations, and thereby to slow down the tumor growth. We establish the well-posedness of the problem and the continuity of the control-to-state mapping, the existence of a minimizer of the objective functional, and its Fréchet differentiability in suitable Banach spaces with respect to the control and with respect to time. Moreover, we derive the first-order necessary conditions that an optimal control has to satisfy. In the second part of the paper, we illustrate our theoretical results with numerical simulations using MRI data from the University Hospital of Poitiers.

Keywords: Cahn-Hilliard equation, well-posedness, optimal control, lactate kinetics, adjoint equations, Fréchet differentiability with respect to the control, numerical simulations

DOI: 10.3233/ASY-221823

Journal: Asymptotic Analysis, vol. 133, no. 4, pp. 555-586, 2023