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In vitro cytocompatibility evaluation of chitosan/graphene oxide 3D scaffold composites designed for bone tissue engineering

Issue title: Frontiers in Biomedical Engineering and Biotechnology – Proceedings of the 3rd International Conference on Biomedical Engineering and Biotechnology, 25–28 September 2014, Beijing, China

Article type: Research Article

Authors: Dinescu, Sorina | Ionita, Mariana | Pandele, Andreea Madalina | Galateanu, Bianca; | Iovu, Horia | Ardelean, Aurel | Costache, Marieta | Hermenean, Anca;

Affiliations: Department of Biochemistry and Molecular Biology, University of Bucharest, 91-95 Splaiul Independentei, 050095 Bucharest, Romania | University Politehnica of Bucharest, Calea Victoriei 149, 010072 Bucharest, Romania | Department of Experimental and Applied Biology, Institute of Life Sciences, Vasile Goldis Western University of Arad, 86 Rebreanu, 310414 Arad, Romania

Note: [] Corresponding author: Anca Hermenean, Department of Experimental and Applied Biology, Institute of Life Sciences, Vasile Goldis Western University of Arad, 86 Rebreanu, 310414 Arad, Romania. Tel.:+40257282839; Fax: +40257282839; E-mail: [email protected].

Keywords: Chitosan, graphene oxide, 3D scaffold, biocompatibility, bone tissue engineering

DOI: 10.3233/BME-141037

Journal: Bio-Medical Materials and Engineering, vol. 24, no. 6, pp. 2249-2256, 2014

Published: 2014
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Abstract

Extensively studied nowadays, graphene oxide (GO) has a benefic effect on cell proliferation and differentiation, thus holding promise for bone tissue engineering (BTE) approaches. The aim of this study was not only to design a chitosan 3D scaffold improved with GO for optimal BTE, but also to analyze its physicochemical properties and to evaluate its cytocompatibility and ability to support cell metabolic activity and proliferation. Overall results show that the addition of GO in the scaffold's composition improved mechanical properties and pore formation and enhanced the bioactivity of the scaffold material for tissue engineering. The new developed CHT/GO 3 wt% scaffold could be a potential candidate for further in vitro and in vivo osteogenesis studies and BTE approaches.

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