Genetic advancement in the detection of Systemic Lupus Erythematosus (SLE)

Article type: Research Article

Authors: Singh, Akshat Pratap^a | Shaikh, Mohammad Kamran^{b; *} | Borker, Anjali^c | Bandre, Gulshan^d

Affiliations: [a] Datta Meghe Medical College, Nagpur Datta Meghe Institute of Higher Education and Research Deemed University, Sawangi, Wardha, India | [b] Community Medicine, Datta Meghe Medical College, Nagpur Datta Meghe Institute of Higher Education and Research Deemed University, Sawangi, Wardha, India | [c] Jawaharlal Nehru Medical College, Wardha Datta Meghe Institute of Higher Education and Research Deemed University, Sawangi, Wardha, India | [d] JRF Microbiology, Jawaharlal Nehru Medical College, Wardha Datta Meghe Institute of Higher Education and Research Deemed University, Sawangi, Wardha, India

Correspondence: [*] Corresponding author: Mohammad Kamran Shaikh, Assistant Professor, Community Medicine, Datta Meghe Medical College, Nagpur. Datta Meghe Institute of Higher Education and Research (DU) Sawangi, Wardha, India. E-mail: [email protected].

Abstract: The disease lupus, also known as systemic lupus erythematosus (SLE), is an autoimmune condition, chronic in nature, that can affect any organ in the body. The immune system of the body becomes hyperactive in lupus, attacking normal tissues and organs such as the skin, skeletal, renal, brain, heart, lungs, and blood. Normally, the immunologic response protects the body against outside susceptibilities. Periods of illness, known as flares, and times of wellness, known as remissions, are characteristics of lupus. Lupus is challenging to diagnose since its symptoms are vastly adherent and often mistaken for those of other illnesses. The presence of complexities in this illness cannot be proven with a single laboratory test. Lupus has no recognised cause or treatment as of yet. However, research is going on to achieve improved health outcomes, and early identification and treatment are essential. Lupus has no recognised cause or treatment as of yet. Early detection and treatment, which can typically reduce a disease’s severity and course, are essential to enhancing health outcomes. NSAIDs, antimalarials, and steroids (including cortisone and others) are widely used to treat lupus. Patients with lupus may also receive cytotoxic chemotherapy comparable to chemotherapy used to treat cancer. Patients with lupus may also receive cytotoxic chemotherapy comparable to chemotherapy used to treat cancer. This well-known and respected resource has a new edition that blends basic and clinical science to present a translational medicine concept. A helpful resource for professionals in the diagnosis and treatment of Systemic Lupus Erythematous patients, SLE serves as a reference for hospital libraries and as a tool for measuring clinical activity for drug development and fundamental research. Beautifully depicted and in full colour throughout Basic science part has been enhanced to let readers concentrate on the most recent molecular medicine techniques and how they affect the expression and treatment of diseases.

Keywords: Biomarkers, IFI27, immune infiltration, integrated bioinformatics, epidemiology, genetic, polymorphism

DOI: 10.3233/JCB-230121

Journal: Journal of Cellular Biotechnology, vol. 10, no. 1, pp. 35-43, 2024