Affiliations: Kazan Children's Municipal Hospital, Kazan, Republic of Tatarstan, Russian Federation | Department of Basic and Clinical Pharmacology, Kazan Federal University, Kazan, Republic of Tatarstan, Russian Federation
Note: [] Address for correspondence: Lilia E. Ziganshina, Department of Basic and Clinical Pharmacology, Kazan Federal University, Kazan, Republic of Tatarstan, Russian Federation. E-mail: [email protected]
Abstract: Pharmacoepidemiology analysis of efficacy and safety of antiepileptics was carried out in children (3 months–18 years old) registered with municipal children's epilepsy services: 548 children in 2005, 718 – In 2007 and 32 – In 2011. We used remission lasting for 1 year or longer, and 3 years or longer as primary effectiveness outcomes, and total number of people with adverse effects as a safety outcome. We found no advantages of newer antiepileptics over the older ones in terms of either efficacy or safety. Long-term follow up (more than 3 years) showed higher treatment response rate in patients with childhood versus juvenile absence epilepsy.
Keywords: Pharmacoepidemiology of antiepileptics, efficacy, safety
