Nicotinic acid derivative (xanthinol nicotinate) induced bullous eruption

Article type: Research Article

Authors: Khan, Sohil A.^; | Rodrigues, Gabriel | Rao, Padma G.M.

Affiliations: Department of Pharmacy Practice, Manipal College of Pharmaceutical Sciences, Manipal, India | Department of Surgery, Kasturba Medical College and Hospital, Manipal, India

Note: [] Corresponding author: Sohil A. Khan, Faculty and Research Scholar, 4th floor, Dept. of Pharmacy Practice, S S Cancer Hospital and Research Centre, Manipal-576 104, Karnataka, India. E-mail: [email protected].

Abstract: Xantinol nicotinate, a nicotinic acid derivative is used in the management of peripheral and cerebral vascular disorders and in hyperlipidaemias for over 40 years. Nicotinic acid derivatives have been associated with dermatological adverse effects. Flushing is claimed to be less frequent than with nicotinic acid, but has nevertheless been repeatedly observed. We present here a case of bullous eruptions due to xanthinol nicotinate, a probable reaction according to the Naranjo Adverse Drug Reaction Probability Scale.

Journal: International Journal of Risk and Safety in Medicine, vol. 18, no. 3, pp. 159-162, 2006