Metabolic effects on infants born to mothers with Gestational Impaired Glucose Tolerance (G‐IGT)

Article type: Research Article

Authors: Savona‐Ventura, C.^; | Schranz, A.G.

Affiliations: Diabetic Pregnancy Joint Clinic, Department of Obstetrics‐Gynaecology, St. Luke's Teaching Hospital, Gwardamangia, Malta | Diabetic Clinic, Department of Medicine, St. Luke's Teaching Hospital, Gwardamangia, Malta

Note: [] Address for correspondence: Northwynds, 7 Antonio Zammit Street, Gharghur Nxr 08, Malta. Tel.: +356 21435396; Fax: +356 21244766; E‐mail: [email protected].

Abstract: Gestational Impaired Glucose Tolerance (G‐IGT) is generally assumed to be of no significance to the developing fetus. The present study, comparing the fetal characteristics of 28 infants born to G‐IGT mothers with those of 237 infants born to mothers with normal glucose tolerance, confirms that G‐IGT has no effects on the anthropomorphic characteristics of the newborn infant. However, the mild carbohydrate disorder is shown to affect adversely the intrauterine millieu interieur causing a mild derangement to the fetal pancreatic beta cells.

Keywords: Diabetes and pregnancy, glucose intolerance, perinatal outcome

Journal: International Journal of Risk and Safety in Medicine, vol. 14, no. 3-4, pp. 95-98, 2001