Huge Proteins in The Human Proteome and Their Participation in Hereditary Diseases

Article type: Research Article

Authors: Sakharkar, Meena Kishore | Kangueane, Pandjassarame | Sakharkar, Kishore Ramaji | Zhong, Zhaowei

Affiliations: Nanyang Centre for Supercomputing and Visualization, MAE, Nanyang Technological University, Singapore | National University Medical Institute, National University of Singapore, Singapore

Note: [] Corresponding author. E-mail: [email protected]

Abstract: Protein lengths vary considerably from a few to thousands of amino acids and length variations are documented to have multiple effects. A computational approach to investigate the functional impact of protein length variation in genetic disorders is presented. The genes for huge proteins are found to have more introns. Our analysis also shows greater involvement of huge proteins in hereditary diseases.

Keywords: Huge proteins, protein length, human, disease, OMIM

Journal: In Silico Biology, vol. 6, no. 4, pp. 275-279, 2006