Affiliations: [a] Islamic Azad University, Hamadan Branch, Hamadan, Iran | [b] Neurophysiology Research Center, Hamadan University of Medical Sciences, Hamadan, Iran | [c] Faculty of Paramedicine, Hamadan University of Medical Sciences, Hamadan, Iran | [d] Research Center for Molecular Medicine, Hamadan University of Medical Sciences, Hamadan, Iran | [e] Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran | [f] Urogenital Stem Cell Research, Shahid Beheshti University of Medical Sciences, Tehran, Iran | [g] Department of Microbiology, Hamadan University of Medical Sciences, Hamadan, Iran
Abstract: Schizophrenia is a destructive clinical syndrome with diverse mental pathologies. Different mechanisms and factors have a role in this disease. A possible mechanism is that teratogenic viruses cause brain changes and results in the disease appearance. The schizophrenia patients were diagnosed by psychologists and with the consent of patients, five CC of venous blood was drawn. Than Serum samples were isolated and immunoglobulin M (IgM) and immunoglobulin G (IgG) antibodies against herpes simplex virus-1 (HSV-1), herpes simplex virus-2 (HSV-2) and cytomegalovirus (CMV) were quantified by ELISA sandwich kit. The Results showed that anti-CMV and anti-HSV1 and anti-HSV2 IgG antibodies in schizophrenia patients were increased significantly (p< 0.05). The increasing of the anti-HSV2 IgM was also observed but increasing amount of the anti-HSV1 IgM was not statistically significant (p< 0.05). Therefore, as a result of this study CMV and HSV1 and HSV2 infection can probably intensify the symptoms in schizophrenia patients.
