Determining the IgM and IgG antibody titer against CMV and helicobacter pylori in the serum of multiple sclerosis patients comparing to the control group in Hamadan

Article type: Research Article

Authors: Salim, Masome Afiati^a | Eftekharian, Mohammad Mahdi^{b; c; *} | Taheri, Mohammad^{d; *} | Yousef Alikhani, Mohammad^e

Affiliations: [a] Islamic Azad University, Hamadan Branch, Hamadan, Iran | [b] Neurophysiology Research Center, Hamadan University of Medical Sciences, Hamadan, Iran | [c] Research Center for Molecular Medicine, Hamadan University of Medical Sciences, Hamadan, Iran | [d] Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran | [e] Department of Microbiology, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran

Correspondence: [*] Corresponding authors: Mohammad Mahdi Eftekharian, Neurophysiology Research Center, Hamadan University of Medical Sciences, Fahmideh Blvd. Hamadan, Iran. Tel: +98 8132520185; E-mail: [email protected];MohammadTaheri,DepartmentofMedicalGenetics,FacultyofMedicine,ShahidBeheshtiUniversityofMedicalSciences,Tehran,Iran.Address:8thFloor,SBUMSBldg.,NexttoAyatollahTaleghaniHospital,Evin,Tehran,Iran.Postcode:198396-3113.Tel:+982177635431;Fax:[email protected].

Abstract: BACKGROUND: Multiple sclerosis (MS) is a chronic autoimmune disease that disables central nervous system (CNS) system. Cytomegalovirus (CMV) probably has an important role in the MS pathology. The infection with helicobacter pylori also is recognized as a protective agent against MS in female. METHODS: Serum samples were isolated and frozen at -70∘C. The earlier mentioned anti-virus antibodies and antibacterial antibodies were quantified by Elisa kit. RESULTS: The results showed that IgG antibody average value against cytomegalovirus in the blood of multiple sclerosis patients not only decreased but also was significant statistically (p< 0.05). IgM and IgG antibodies average value in the blood of multiple sclerosis patients against helicobacter pylori shown a statistically significant decrease (p< 0.05). CONCLUSION: Therefore it may be considered that probably helicobacter pylori presence in the individuals especially in female can alleviate MS signs. CMV infection can intensify the symptoms in multiple sclerosis patients.

Keywords: Multiple sclerosis, helicobacter pylori, cytomegalovirus, ELISA, Hamadan

DOI: 10.3233/HAB-170317

Journal: Human Antibodies, vol. 26, no. 1, pp. 23-28, 2018