Investigation of the correlation between some immune system and biochemical indicators in patients with type 2 diabetes

Article type: Research Article

Authors: Eftekharian, Mohammad Mahdi^{a; b; c; d} | Karimi, Jamshid^e | Safe, Mojgansadat^f | Sadeghian, Ahmad^g | Borzooei, Shiva^h | Siahpoushi, Ehsan^{i; *}

Affiliations: [a] Department of Medical Laboratory Sciences, School of Paramedicine, Hamadan University of Medical Sciences, Hamadan, Iran | [b] Research Center for Molecular Medicine, Hamadan University of Medical Sciences, Hamadan, Iran | [c] Neurophysiology Research Center, Hamadan University of Medical Sciences, Hamadan, Iran | [d] Molecularimmunology Research Group, Hamadan University of Medical Sciences, Hamadan, Iran | [e] Department of Biochemistry, Hamadan University of Medical Sciences, Hamadan, Iran | [f] School of Health, Hamadan University of Medical Sciences, Hamadan, Iran | [g] Taamin-e-ejtemaee Hospital, Hamadan, Iran | [h] Department of Internal Medicine, Faculty of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran | [i] Department of Biochemistry, Students Research Center, Hamadan University of Medical Sciences, Hamadan, Iran

Correspondence: [*] Corresponding author: Ehsan Siahpoushi, Students Research Center, Hamadan University of Medical Sciences, Fahmideh Blvd., Hamadan, Iran. E-mail:[email protected]

Abstract: AIMS/INTRODUCTION: Since changes in some immune system indicators such as leukocyte count and neutrophil to lymphocyte ratio in the blood and Inflammation is directly in relation with the pathogenesis of type 2 diabetes, metabolic syndrome and atherosclerosis, measuring these indicators in patients with type 2 diabetes and comparing them with control group can be a suitable indicator of Inflammation and prognosis of the disease. MATERIALS AND METHODS: The current study was done on 75 patients with type 2 diabetes and 72 healthy individuals as patient and healthy group respectively. The selected groups have been matched for age and sex. Fasting blood sugar, lipid profile including triglycerides, total cholesterol, HDL, LDL, as well as the number of white blood cells, neutrophils, lymphocytes, neutrophils to lymphocytes ratio were measured and analyzed in both groups. RESULTS: The results demonstrated that there is a significant relationship between the number of white blood cells and increase in blood sugar and also between the neutrophil to lymphocyte ratio and increase in Fasting blood sugar and triglycerides parameters. Furthermore, the average of fasting blood sugar, triglycerides, total cholesterol, LDL and neutrophil to lymphocyte ratio in patient with type 2 diabetes is significantly higher than control group. CONCLUSION: Considering the findings of current study, we showed the inflammation and the pathogenesis caused by type 2 diabetes can be attributed to neutrophil to lymphocyte ratio.

Keywords: Diabetes, neutrophil to lymphocyte ratio, inflammation

DOI: 10.3233/HAB-150290

Journal: Human Antibodies, vol. 24, no. 1-2, pp. 25-31, 2016